Combined Preparation of Human Olfactory Ensheathing Cells in the Therapy of Post-Traumatic Cysts of the Spinal Cord

被引：3

作者：

Voronova, A. D. ^{[1
]}

Stepanova, O. V. ^{[1
,4
]}

Valikhov, M. P. ^{[1
,4
]}

Chadin, A. V. ^{[1
]}

Semkina, A. S. ^{[1
]}

Karsuntseva, E. K. ^{[1
,2
]}

Fursa, G. A. ^{[1
,2
]}

Reshetov, I. V. ^{[3
]}

Chekhonin, V. P. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Dept Fundamental & Appl Neurobiol, VP Serbsky Fed Med Res Ctr Psychiat & Narcol, Moscow, Russia

[2] MV Lomonosov Moscow State Univ, Moscow, Russia

[3] Sechenov Univ, Minist Hlth Russian Federat, IM Sechenov First Moscow State Med Univ, Univ Clin Hosp 1, Moscow, Russia

[4] Minist Hlth Russian Federat, Dept Neurohumoral & Immunol Studies, Natl Med Res Ctr Cardiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

neural stem; progenitor cells; olfactory ensheathing cells; human olfactory mucosa; cell therapy; post-traumatic cysts of spinal cord; NEURAL STEM-CELLS; TRANSPLANTATION; INJURY; REPAIR;

D O I：

10.1007/s10517-020-04925-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In experiments on rats, co-transplantation of olfactory ensheathing cells of the human olfactory mucosa and neural stem/progenitor cells from the same source into post-traumatic cysts of the spinal cord led to improvement of the motor activity of the hind limbs and reduced the size of the cysts in some animals by 4-12%. The transplantation of a combination of the olfactory mucosa cells is effective and can be used in preclinical trials for the treatment of spinal cord injuries.

引用

页码：539 / 543

页数：5

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