Neuroprotection of apelin and its signaling pathway

被引：100

作者：

Cheng, Baohua ^{[1
]}

Chen, Jing ^{[1
]}

Bai, Bo ^{[1
]}

Xin, Qing ^{[1
]}

机构：

[1] Jining Med Univ, Dept Neurol, Jining City, Shandong, Peoples R China

来源：

PEPTIDES | 2012年 / 37卷 / 01期

关键词：

Apelin; APJ; Neuroprotection; Neurons; Central nervous system; ENDOGENOUS LIGAND APELIN; HUMAN APJ RECEPTOR; TISSUE DISTRIBUTION; EXCITOTOXIC INJURY; MESSENGER-RNA; FOOD-INTAKE; RAT-BRAIN; EXPRESSION; PEPTIDE; NEURONS;

D O I：

10.1016/j.peptides.2012.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a native ligand of the apelin receptor (APJ). Some research has found that apelin peptides alter blood pressure, feeding behavior, and pituitary hormone release. However, a new neuroprotective effect of apelin peptides was only recently discovered. This review summarizes the evidence of apelin-neuroprotection, which has the potential to cure acute and chronic neurological diseases. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：171 / 173

页数：3

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