Functional regulation of monocyte-derived dendritic cells by microRNAs

被引：15

作者：

Zhan, Yifan ^{[1
,2
]}

Wu, Li ^{[3
,4
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[3] Tsignhua Univ, Sch Med, Beijing 100084, Peoples R China

[4] Peking Univ, Joint Ctr Life Sci, Beijing 100084, Peoples R China

来源：

PROTEIN & CELL | 2012年 / 3卷 / 07期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

dendritic cells; microRNA; function; COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; T-CELLS; IN-VIVO; LANGERHANS CELLS; GM-CSF; STEADY-STATE; BONE-MARROW; LISTERIA-MONOCYTOGENES; RECEPTOR EXPRESSION;

D O I：

10.1007/s13238-012-0042-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.

引用

页码：497 / 507

页数：11

共 88 条

[1] TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection [J].

Aldridge, Jerry R., Jr. ;

Moseley, Carson E. ;

Boltz, David A. ;

Negovetich, Nicholas J. ;

Reynolds, Cory ;

Franks, John ;

Brown, Scott A. ;

Doherty, Peter C. ;

Webster, Robert G. ;

Thomas, Paul G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5306-5311

[2] Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells [J].

Aliberti, J ;

Schulz, O ;

Pennington, DJ ;

Tsujimura, H ;

Sousa, CRE ;

Ozato, K ;

Sher, A .

BLOOD, 2003, 101 (01) :305-310

[3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[4] Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells [J].

Bedoui, Sammy ;

Whitney, Paul G. ;

Waithman, Jason ;

Eidsmo, Liv ;

Wakim, Linda ;

Caminschi, Irina ;

Allan, Rhys S. ;

Wojtasiak, Magdalena ;

Shortman, Ken ;

Carbone, Francis R. ;

Brooks, Andrew G. ;

Heath, William R. .

NATURE IMMUNOLOGY, 2009, 10 (05) :488-495

[5] Origin of the Lamina Propria Dendritic Cell Network [J].

Bogunovic, Milena ;

Ginhoux, Florent ;

Helft, Julie ;

Shang, Limin ;

Hashimoto, Daigo ;

Greter, Melanie ;

Liu, Kang ;

Jakubzick, Claudia ;

Ingersoll, Molly A. ;

Leboeuf, Marylene ;

Stanley, E. Richard ;

Nussenzweig, Michel ;

Lira, Sergio A. ;

Randolph, Gwendalyn J. ;

Merad, Miriam .

IMMUNITY, 2009, 31 (03) :513-525

[6] Differentiation of Inflammatory Dendritic Cells Is Mediated by NF-κB1-Dependent GM-CSF Production in CD4 T Cells [J].

Campbell, Ian K. ;

van Nieuwenhuijze, Annemarie ;

Segura, Elodie ;

O'Donnell, Kristy ;

Coghill, Elise ;

Hommel, Mirja ;

Gerondakis, Steve ;

Villadangos, Jose A. ;

Wicks, Ian P. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (09) :5468-5477

[7] The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner [J].

Carotta, Sebastian ;

Dakic, Aleksandar ;

D'Amico, Angela ;

Pang, Swee Heng Milon ;

Greig, Kylie T. ;

Nutt, Stephen L. ;

Wu, Li .

IMMUNITY, 2010, 32 (05) :628-641

[8]

Cekaite Lina, 2010, Front Biosci (Elite Ed), V2, P818

[9] MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells [J].

Ceppi, Maurizio ;

Pereira, Patricia M. ;

Dunand-Sauthier, Isabelle ;

Barras, Emmanuele ;

Reith, Walter ;

Santos, Manuel A. ;

Pierre, Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2735-2740

[10] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

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