Potential of microRNAs for cancer diagnostics, prognostication and therapy

被引：70

作者：

Garzon, Ramiro ^{[1
]}

Marcucci, Guido ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Med, Div Hematol, Columbus, OH 43210 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2012年 / 24卷 / 06期

关键词：

diagnosis; microRNA; prognosis; therapeutics; SMALL-MOLECULE INHIBITORS; ACUTE MYELOID-LEUKEMIA; TISSUE; EXPRESSION; IDENTIFICATION; BIOMARKERS; PROFILES; IDENTIFY; PLASMA; RNAS;

D O I：

10.1097/CCO.0b013e328358522c

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of review MicroRNAs (miRNAs) are small regulatory RNAs that are frequently deregulated in cancer and have shown great potential as biomarkers for cancer diagnosis and prognostication. Recent studies also support great promise in targeting miRNAs in cancer. Recent findings In this review, we will discuss the most important aspects about the use of miRNAs for the diagnosis, prognosis and therapy in cancer, including current pitfalls and future directions. Summary The definitive establishment of miRNAs as biomarkers and as therapeutic targets in cancer will likely have a profound impact on clinical practice and research.

引用

页码：655 / 659

页数：5

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