Anti-transglutaminase 6 Antibody Development in Children With Celiac Disease Correlates With Duration of Gluten Exposure

被引：13

作者：

De Leo, Luigina ^{[1
]}

Aeschlimann, Daniel ^{[2
,3
]}

Hadjivassiliou, Marios ^{[4
]}

Aeschlimann, Pascale ^{[2
,3
]}

Salce, Nicola ^{[1
]}

Vatta, Serena ^{[1
]}

Ziberna, Fabiana ^{[1
]}

Cozzi, Giorgio ^{[1
]}

Martelossi, Stefano ^{[1
]}

Ventura, Alessandro ^{[1
,5
]}

Not, Tarcisio ^{[1
,5
]}

机构：

[1] Inst Maternal & Child Hlth IRCCS Burlo Garofolo T, Trieste, Italy

[2] Cardiff Univ, Sch Dent, Matrix Biol & Tissue Repair Res Unit, Cardiff, S Glam, Wales

[3] Cardiff Univ, Coll Biomed & Life Sci, Arthrit Res UK Biomed & Bioengn Ctr Excellence, Cardiff, S Glam, Wales

[4] Royal Hallmshire Hosp, Dept Neurol, Sheffield, S Yorkshire, England

[5] Univ Trieste, Trieste, Italy

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2018年 / 66卷 / 01期

关键词：

gluten-free diet; neurological disorders; transglutaminase; 6; DERMATITIS-HERPETIFORMIS; AUTOANTIBODIES; SENSITIVITY; PREVALENCE; DIAGNOSIS; ATAXIA;

D O I：

10.1097/MPG.0000000000001642

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives:Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic gluten intolerance, and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders.Methods:Anti-TG6 (IgA/IgG) were measured by ELISA in sera of children with biopsy-proven CD and of children experiencing gastrointestinal disorders. CD patients positive for anti-TG6 were retested after 2 years of gluten-free diet (GFD).Results:We analyzed the sera of 274 CD children and of 121 controls. Anti-TG6 were detected in 68/274 (25%) CD patients and in 19/121 (16%) controls, with significant difference between the 2 groups (P=0.04). None of the CD patients and of the controls testing positive for anti-TG6 were experiencing neurological disorders. Eleven of 18 (61%) CD patients with other autoimmune diseases were positive for anti-TG6. In CD patients, a significant correlation between the gluten exposure before the CD diagnosis and anti-TG6 concentration was found (P=0.006 for IgA; P<0.0001 for IgG). After GFD anti-TG6 concentrations were significantly reduced (P<0.001). No significant correlation was observed between anti-TG6 and anti-TG2 serum concentrations.Conclusions:Anti-TG6 are more prevalent in children with untreated CD in the absence of overt neurological disorders. The synthesis of the anti-TG6 is related to a longer exposure to gluten before the CD diagnosis, and the autoimmunity against TG6 is gluten dependent and disappeared during GFD.

引用

页码：64 / 68

页数：5