Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3-yl)-2,3′-biindolin-3-ones

被引：45

作者：

Qin, Wen-Bing ^{[1
]}

Chang, Qiong ^{[1
]}

Bao, Yun-Hong ^{[1
]}

Wang, Ning ^{[1
]}

Chen, Zheng-Wang ^{[1
]}

Liu, Liang-Xian ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 44期

关键词：

FUNCTIONALIZATION; POLYMERIZATION; ROUTES;

D O I：

10.1039/c2ob26390d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, convenient and efficient metal-free catalyzed oxidative trimeric reaction of indoles toward a variety of 2-(1H-indol-3-yl)-2,3'-biindolin-3-one derivatives in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative homocoupling reaction by using TEMPO in air as an environmentally benign oxidant. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.

引用

页码：8814 / 8821

页数：8

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