Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

被引：4
|
作者：
Leroy, Kaat [1 ]
Pieters, Alanah [1 ]
Tabernilla, Andres [1 ]
Cooreman, Axelle [1 ]
Van Campenhout, Raf [1 ]
Cogliati, Bruno [2 ]
Vinken, Mathieu [1 ]
机构：
[1] Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol, Brussels, Belgium
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Cidade Univ, Sao Paulo, Brazil
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS | 2020年 / 23卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Connexin; gap junction intercellular communication; hepatocarcinogenicity; non-genotoxic carcinogenic compounds; risk assessment; hemichannel; in vivo; in vitro; HEPATOCELLULAR-CARCINOMA CELLS; ACTIVATED PROTEIN-KINASE; LIVER EPITHELIAL-CELLS; DI-ISONONYL PHTHALATE; BETA-OXIDATION PBOX; RAT-LIVER; CONNEXIN; 32; IN-VITRO; NONGENOTOXIC CARCINOGENS; DOWN-REGULATION;
D O I：
10.1080/10937404.2020.1781010
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The focus in this review is placed upon the mechanistic scenarios that underlie these adverse effects. Further, the potential use of gap junctional activity as anin vitrobiomarker to identify non-genotoxic hepatocarcinogenic chemicals is discussed.
引用
收藏
页码：255 / 275
页数：21
相关论文
共 50 条
  • [41] HuR Regulates Gap Junctional Intercellular Communication by Controlling β-Catenin Levels and Adherens Junction Integrity
    Ale-Agha, Niloofar
    Galban, Stefanie
    Sobieroy, Christiane
    Abdelmohsen, Kotb
    Gorospe, Myriam
    Sies, Helmut
    Klotz, Lars-Oliver
    HEPATOLOGY, 2009, 50 (05) : 1567 - 1576
  • [42] Effect of perfluorooctane sulfonate on viability, maturation and gap junctional intercellular communication of porcine oocytes in vitro
    Dominguez, A.
    Salazar, Z.
    Arenas, E.
    Betancourt, M.
    Ducolomb, Y.
    Gonzalez-Marquez, H.
    Casas, E.
    Teteltitla, M.
    Bonilla, E.
    TOXICOLOGY IN VITRO, 2016, 35 : 93 - 99
  • [43] Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells
    Lin, Ta-Chin
    Wang, Kai-Hung
    Chuang, Kuo-Hsiang
    Kao, An-Pei
    Kuo, Tsung-Cheng
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2021, 68 (03) : 676 - 682
  • [44] Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells
    Upham, BL
    Kang, KS
    Cho, HY
    Trosko, JE
    CARCINOGENESIS, 1997, 18 (01) : 37 - 42
  • [45] Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells
    Kim, Yeon Ju
    Kim, Jangho
    Tian, Chunjie
    Lim, Hye Jin
    Kim, Young Sun
    Chung, Jong Hoon
    Choung, Yun-Hoon
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (19) : 3859 - 3871
  • [46] Gap junctional intercellular communication: A new mechanism in pathophysiology of migraine with aura. Therapeutic applications
    Sarrouilhe, D.
    Dejean, C.
    PATHOLOGIE BIOLOGIE, 2012, 60 (06): : 392 - 398
  • [47] Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat
    Hokaiwado, N
    Asamoto, M
    Ogawa, K
    Shirai, T
    TOXICOLOGIC PATHOLOGY, 2005, 33 (06) : 695 - 701
  • [48] Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication
    Nielsen, M
    Ruch, RJ
    Vang, O
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 275 (03) : 804 - 809
  • [49] Loss of Function of the Retinoblastoma Gene Affects Gap Junctional Intercellular Communication and Cell Fate in Osteoblasts
    Pendleton, Elisha
    Ketner, Anthony
    Ransick, Phil
    Ardekani, Doug
    Bodenstine, Thomas
    Chandar, Nalini
    BIOLOGY-BASEL, 2024, 13 (01):
  • [50] Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles
    Ale-Agha, Niloofar
    Albrecht, Catrin
    Klotz, Lars-Oliver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (01) : 44 - 47
12345