Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

被引：4
|
作者：
Leroy, Kaat [1 ]
Pieters, Alanah [1 ]
Tabernilla, Andres [1 ]
Cooreman, Axelle [1 ]
Van Campenhout, Raf [1 ]
Cogliati, Bruno [2 ]
Vinken, Mathieu [1 ]
机构：
[1] Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol, Brussels, Belgium
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Cidade Univ, Sao Paulo, Brazil
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS | 2020年 / 23卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Connexin; gap junction intercellular communication; hepatocarcinogenicity; non-genotoxic carcinogenic compounds; risk assessment; hemichannel; in vivo; in vitro; HEPATOCELLULAR-CARCINOMA CELLS; ACTIVATED PROTEIN-KINASE; LIVER EPITHELIAL-CELLS; DI-ISONONYL PHTHALATE; BETA-OXIDATION PBOX; RAT-LIVER; CONNEXIN; 32; IN-VITRO; NONGENOTOXIC CARCINOGENS; DOWN-REGULATION;
D O I：
10.1080/10937404.2020.1781010
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The focus in this review is placed upon the mechanistic scenarios that underlie these adverse effects. Further, the potential use of gap junctional activity as anin vitrobiomarker to identify non-genotoxic hepatocarcinogenic chemicals is discussed.
引用
收藏
页码：255 / 275
页数：21
相关论文
共 50 条
  • [1] Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication
    Choi, Eun J.
    Yeo, Joo H.
    Yoon, Sei M.
    Lee, Jinu
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [2] Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells
    Serrano-Rubi, Mauricio
    Jimenez, Lidia
    Martinez-Rendon, Jacqueline
    Cereijido, Marcelino
    Ponce, Arturo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (01) : 1 - 18
  • [3] Defective gap junctional intercellular communication in the carcinogenic process
    Mesnil, M
    Crespin, S
    Avanzo, JL
    Zaidan-Dagli, ML
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2005, 1719 (1-2): : 125 - 145
  • [4] Intercellular calcium signaling and gap junctional communication in astrocytes
    Giaume, C
    Venance, L
    GLIA, 1998, 24 (01) : 50 - 64
  • [5] The chemopreventive role of dietary phytochemicals through gap junctional intercellular communication
    Leone, Antonella
    Longo, Cristiano
    Trosko, James E.
    PHYTOCHEMISTRY REVIEWS, 2012, 11 (2-3) : 285 - 307
  • [6] GINGKO BILOBA EXTRACTS PROTECT AUDITORY HAIR CELLS FROM CISPLATIN-INDUCED OTOTOXICITY BY INHIBITING PERTURBATION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION
    Choi, S. J.
    Kim, S. W.
    Lee, J. B.
    Lim, H. J.
    Kim, Y. J.
    Tian, C.
    So, H. S.
    Park, R.
    Choung, Y-H.
    NEUROSCIENCE, 2013, 244 : 49 - 61
  • [7] Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication
    Ma, Wenhui
    Zhang, Xuemin
    Shi, Shushan
    Zhang, Yingze
    NEUROPEPTIDES, 2013, 47 (03) : 179 - 186
  • [8] Effect of phenobarbital on hepatic gap junctional intercellular communication in rats
    Ito, S
    Tsuda, M
    Yoshitake, A
    Yanai, T
    Masegi, T
    TOXICOLOGIC PATHOLOGY, 1998, 26 (02) : 253 - 259
  • [9] The modulation of gap-junctional intercellular communication by lipid rafts
    Defamie, Norah
    Mesnil, Marc
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2012, 1818 (08): : 1866 - 1869
  • [10] Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity
    Vinken, Mathieu
    Doktorova, Tatyana
    Decrock, Elke
    Leybaert, Luc
    Vanhaecke, Tamara
    Rogiers, Vera
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009, 44 (04) : 201 - 222
12345