Association Between Cerebrospinal Fluid Biomarkers and Age-related Brain Changes in Patients with Normal Pressure Hydrocephalus

被引：16

作者：

Taghdiri, Foad ^{[1
,2
]}

Gumus, Melisa ^{[1
]}

Algarni, Musleh ^{[3
,4
]}

Fasano, Alfonso ^{[2
,3
,4
,5
]}

Tang-Wai, David ^{[2
]}

Tartaglia, Maria Carmela ^{[1
,2
]}

机构：

[1] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, 60 Leonard Ave, Toronto, ON M5T 2S8, Canada

[2] Univ Toronto, Div Neurol, Dept Med, Toronto, ON, Canada

[3] UHN, Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada

[4] Univ Toronto, Div Neurol, Toronto, ON, Canada

[5] Krembil Brain Inst, Toronto, ON, Canada

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

CSF BIOMARKERS; EVANS INDEX; DIAGNOSIS; TAU; DISCRIMINATION; DISEASE;

D O I：

10.1038/s41598-020-66154-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our study aimed to: 1)investigate the diagnostic utility of CSF A beta 42, t-tau, and p-tau to differentiate normal-pressure-hydrocephalus(NPH) from Alzheimer's-disease(AD) and normal-controls; and 2)investigate if age and ventricular size affect the levels of CSF biomarkers in NPH patients. We recruited 131 participants: (a)Suspected-NPH: 72 with ventriculomegaly and clinical symptoms of NPH. These participants were then divided into two groups of 1)Probable-NPH (N=38) and 2)Unlikely-NPH (N=34) based on whether participants experienced gait improvement after removal of a large amount of CSF; (b)AD group: 30 participants with CSF biomarkers and cognitive symptoms consistent with AD; (c)Control-group: 29 participants who were cognitively and functionally normal. Lower levels of CSF A beta 42 and p-tau were observed in the probable-NPH compared to the normal controls(444.22 +/- 163.3 vs. 1213.75 +/- 556.5; and 26.05 +/- 9.2 vs. 46.16 +/- 13.3pg/mL; respectively). Lower levels of CSF p-tau and t-tau were found in the probable-NPH compared to the AD(26.05 +/- 9.2 vs. 114.95 +/- 28.2; and 193.29 +/- 92.3 vs. 822.65 +/- 311.5pg/mL; respectively) but the CSF-A beta 42 was low in both the probable-NPH and AD. CSF-A beta 42 correlated with age and Evans-index only in the probable-NPH(r=0.460, p=0.004; and r=-0.530, p=0.001; respectively). Our study supports the hypothesis that age-related atrophy results in better A beta 42 clearance in the CSF because of the increase in the interstitial space.

引用

页数：6

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