Diagnosis and management of hypertension in patients with Cushing's syndrome: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

被引：21

作者：

Fallo, Francesco ^{[1
]}

Di Dalmazi, Guido ^{[2
,3
]}

Beuschlein, Felix ^{[4
,5
,6
]}

Biermasz, Nienke R. ^{[7
,8
]}

Castinetti, Frederic ^{[9
,10
,11
]}

Elenkova, Atanaska ^{[12
]}

Fassnacht, Martin ^{[13
]}

Isidori, Andrea M. ^{[14
]}

Kastelan, Darko ^{[15
]}

Korbonits, Marta ^{[16
]}

Newell-Price, John ^{[17
,18
]}

Parati, Gianfranco ^{[19
,20
]}

Petersenn, Stephan ^{[21
,22
]}

Pivonello, Rosario ^{[23
,24
,25
]}

Ragnarsson, Oskar ^{[26
,27
]}

Tabarin, Antoine ^{[28
]}

Theodoropoulou, Marily ^{[6
]}

Tsagarakis, Stylianos ^{[29
]}

Valassi, Elena ^{[30
,31
]}

Witek, Przemyslaw ^{[32
]}

Reincke, Martin ^{[6
]}

机构：

[1] Univ Padua, Dept Med, Clin Med 3, Padua, Italy

[2] Univ Bologna, Dept Med & Surg Sci, Unit Endocrinol & Diabet Prevent & Care, Bologna, Italy

[3] IRCCS Azienda Osped Univ Bologna, Bologna, Italy

[4] Univ Hosp Zurich USZ, Dept Endocrinol Diabetol & Clin Nutr, Zurich, Switzerland

[5] Univ Zurich UZH, Zurich, Switzerland

[6] Ludwig Maximilians Univ Munchen, LMU Klinikum, Med Klin & Poliklin 4, Munich, Germany

[7] Leiden Univ, Med Ctr, Leiden, Netherlands

[8] European Reference Ctr Rare Endocrine Condit Endo, Leiden, Netherlands

[9] Aix Marseille Univ, INSERM, Marseille Med Genet, Marseille, France

[10] AP HM, Marseille, France

[11] La Concept Hosp, Dept Endocrinol, Marseille, France

[12] Med Univ Sofia, Univ Specialized Hosp Act Treatment Endocrinol US, Dept Endocrinol, Sofia, Bulgaria

[13] Univ Wurzburg, Univ Hosp, Dept Internal Med, Div Endocrinol & Diabet, Wurzburg, Germany

[14] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[15] Zagreb Univ, Sch Med, Univ Hosp Ctr Zagreb, Dept Endocrinol, Zagreb, Croatia

[16] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Ctr Endocrinol, London, England

[17] Univ Sheffield, Sch Med, Dept Oncol & Metab, Sheffield, S Yorkshire, England

[18] Royal Hallamshire Hosp, Sheffield Teaching Hosp NHS Fdn Trust, Dept Endocrinol, Sheffield, S Yorkshire, England

[19] Ist Auxol Italiano, Dept Cardiovasc Neural & Metab Sci, IRCCS, Milan, Italy

[20] Univ Milano Bicocca, Dept Med & Surg, Milan, Italy

[21] ENDOC Ctr Endocrine Tumors, Hamburg, Germany

[22] Univ Duisburg Essen, Essen, Germany

[23] Univ Federico II Napoli, Dipartimento Med Clin & Chirurg, Sez Endocrinol, Naples, Italy

[24] Univ Federico II Napoli, Dipartimento Med Clin & Chirurg, Sez Endocrinol, Unite Androl & Med Riproduz & Sessualita Maschile, Naples, Italy

[25] Univ Naples Federico II, Unesco Chair Hlth Educ & Sustainable Dev, Naples, Italy

[26] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[27] Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden

[28] Univ Bordeaux, CHU Bordeaux, Hop Haut Leveque, Bordeaux, France

[29] Evangelismos Med Ctr, Dept Endocrinol & Diabet, Athens, Greece

[30] Hosp Badalona Germans Trias & Pujol, Endocrinol Unit, Badalona, Spain

[31] Hosp Santa Creu & Sant Pau, CIBERER, Unit 747, Res Ctr Pituitary Dis, Barcelona, Spain

[32] Med Univ Warsaw, Mazovian Brodno Hosp, Dept Internal Med Endocrinol & Diabet, Warsaw, Poland

来源：

JOURNAL OF HYPERTENSION | 2022年 / 40卷 / 11期

关键词：

adrenocorticotrophic hormone; adrenal cortex; cardiovascular; consensus; cortisol; Cushing; glucocorticoid; hypertension; pituitary; position statement; BLOOD-PRESSURE PROFILE; ECTOPIC ACTH-SECRETION; ADRENAL INCIDENTALOMAS; CARDIOVASCULAR RISK; CLINICAL-PRACTICE; SUBCLINICAL HYPERCORTISOLISM; STEROIDOGENESIS INHIBITORS; GENOMIC CHARACTERIZATION; BILATERAL ADRENALECTOMY; DIFFERENTIAL-DIAGNOSIS;

D O I：

10.1097/HJH.0000000000003252

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Endogenous/exogenous Cushing's syndrome is characterized by a cluster of systemic manifestations of hypercortisolism, which cause increased cardiovascular risk. Its biological basis is glucocorticoid excess, acting on various pathogenic processes inducing cardiovascular damage. Hypertension is a common feature in Cushing's syndrome and may persist after normalizing hormone excess and discontinuing steroid therapy. In endogenous Cushing's syndrome, the earlier the diagnosis the sooner management can be employed to offset the deleterious effects of excess cortisol. Such management includes combined treatments directed against the underlying cause and tailored antihypertensive drugs aimed at controlling the consequences of glucocorticoid excess. Experts on endocrine hypertension and members of the Working Group on Endocrine Hypertension of the European Society of Hypertension (ESH) prepared this Consensus document, which summarizes the current knowledge in epidemiology, genetics, diagnosis, and treatment of hypertension in Cushing's syndrome.

引用

页码：2085 / 2101

页数：17

共 194 条

[1] PATHOGENESIS OF CUSHING DISEASE: AN UPDATE ON THE GENETICS OF CORTICOTROPINOMAS [J].

Albani, Adriana ;

Perez-Rivas, Luis G. ;

Reincke, Martin ;

Theodoropoulou, Marily .

ENDOCRINE PRACTICE, 2018, 24 (10) :907-914

[2] The USP8 mutational status may predict long-term remission in patients with Cushing's disease [J].

Albani, Adriana ;

Perez-Rivas, Luis G. ;

Dimopoulou, Christina ;

Zopp, Stephanie ;

Colon-Bolea, Paula ;

Roeber, Sigrun ;

Honegger, Juergen ;

Flitsch, Joerg ;

Rachinger, Walter ;

Buchfelder, Michael ;

Stalla, Guenter K. ;

Herms, Jochen ;

Reincke, Martin ;

Theodoropoulou, Marily .

CLINICAL ENDOCRINOLOGY, 2018, 89 (04) :454-458

[3] Patients with Cushing's syndrome have increased intimal media thickness at different vascular levels: Comparison with a population matched for similar cardiovascular risk factors [J].

Albiger, N. ;

Testa, R. M. ;

Almoto, B. ;

Ferrari, M. ;

Bilora, F. ;

Petrobelli, F. ;

Pagnan, A. ;

Mantero, F. ;

Scaroni, C. .

HORMONE AND METABOLIC RESEARCH, 2006, 38 (06) :405-410

[4] The prevalence and characteristic features of cyclicity and variability in Cushing's disease [J].

Alexandraki, Krystallenia I. ;

Kaltsas, Gregory A. ;

Isidori, Andrea M. ;

Akker, Scott A. ;

Drake, William M. ;

Chew, Shern L. ;

Monson, John P. ;

Besser, G. Michael ;

Grossman, Ashley B. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 160 (06) :1011-1018

[5] THE EFFECT OF AGE ON PREVALENCE OF SECONDARY FORMS OF HYPERTENSION IN 4429 CONSECUTIVELY REFERRED PATIENTS [J].

ANDERSON, GH ;

BLAKEMAN, N ;

STREETEN, DHP .

JOURNAL OF HYPERTENSION, 1994, 12 (05) :609-615

[6] The clinical significance of adrenal incidentalomas [J].

Androulakis, Ioannis I. ;

Kaltsas, Gregory ;

Piaditis, George ;

Grossman, Ashley B. .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 (05) :552-560

[7] Comparison between the clinical characteristics of patients with adrenal incidentalomas and those with hypertension-associated adrenal tumors in a single center in Japan [J].

Aoe, Mari ;

Okada, Akira ;

Usui, Tomoko ;

Manaka, Katsunori ;

Nangaku, Masaomi ;

Makita, Noriko .

ENDOCRINE JOURNAL, 2020, 67 (06) :645-654

[8] Diagnosis and complications of Cushing's syndrome: A consensus statement [J].

Arnaldi, G ;

Angeli, A ;

Atkinson, AB ;

Bertagna, X ;

Cavagnini, F ;

Chrousos, GP ;

Fava, GA ;

Findling, JW ;

Gaillard, RC ;

Grossman, AB ;

Kola, B ;

Lacroix, A ;

Mancini, T ;

Mantero, F ;

Newell-Price, J ;

Nieman, LK ;

Sonino, N ;

Vance, ML ;

Giustina, A ;

Boscaro, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (12) :5593-5602

[9] Effectiveness versus efficacy: The limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome [J].

Aron, DC ;

Raff, H ;

Findling, JW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (06) :1780-1785

[10] Integrated genomic characterization of adrenocortical carcinoma [J].

Assie, Guillaume ;

Letouze, Eric ;

Fassnacht, Martin ;

Jouinot, Anne ;

Luscap, Windy ;

Barreau, Olivia ;

Omeiri, Hanin ;

Rodriguez, Stephanie ;

Perlemoine, Karine ;

Rene-Corail, Fernande ;

Elarouci, Nabila ;

Sbiera, Silviu ;

Kroiss, Matthias ;

Allolio, Bruno ;

Waldmann, Jens ;

Quinkler, Marcus ;

Mannelli, Massimo ;

Mantero, Franco ;

Papathomas, Thomas ;

De Krijger, Ronald ;

Tabarin, Antoine ;

Kerlan, Veronique ;

Baudin, Eric ;

Tissier, Frederique ;

Dousset, Bertrand ;

Groussin, Lionel ;

Amar, Laurence ;

Clauser, Eric ;

Bertagna, Xavier ;

Ragazzon, Bruno ;

Beuschlein, Felix ;

Libe, Rossella ;

de Reynies, Aurelien ;

Bertherat, Jerome .

NATURE GENETICS, 2014, 46 (06) :607-612

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