The Pathophysiologic Roles of TRPM7 Channel

被引：44
|
作者：
Park, Hyun Soo [1 ]
Hong, Chansik [2 ]
Kim, Byung Joo [1 ]
So, Insuk [2 ]
机构：
[1] Pusan Natl Univ, Div Longev & Biofunct Med, Sch Korean Med, Yangsan 626870, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Physiol, Seoul 110799, South Korea
来源：
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | 2014年 / 18卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Disease; Ion Channel; Transient receptor potential melastatin 7; TRPM7; SMOOTH-MUSCLE-CELLS; RECEPTOR POTENTIAL CHANNELS; POTASSIUM CHANNELS; CEREBRAL-ISCHEMIA; PROSTATE-CANCER; KINASES TRPM6; ION CHANNELS; CA2+ ENTRY; MAGNESIUM; CALCIUM;
D O I：
10.4196/kjpp.2014.18.1.15
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2+ and Ca2+, and its channel activity is negatively regulated by free Mg2+ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.
引用
收藏
页码：15 / 23
页数：9
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