Differentiation of neural stem cells into astrocytes by low concentration of pituitary adenylate cyclase-activating polypeptide (PACAP)

被引：0

作者：

Watanabe, Jun ^{[1
,2
]}

Shioda, Seiji ^{[1
]}

Kikuyama, Sakae ^{[2
]}

Nakaya, Kazuyasu ^{[3
]}

Nakajo, Shigeo ^{[3
]}

机构：

[1] Showa Univ, Sch Med, Dept Anat 1, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan

[2] Waseda Univ, Sch Educ, Dept Biol, Shinjuku Ku, Tokyo 1698050, Japan

[3] Showa Univ, Sch Pharmaceut Sci, Biol Chem Lab, Shinagawa Ku, Tokyo 1428555, Japan

来源：

BREATHING, FEEDING AND NEUROPROTECTION | 2006年

关键词：

neural stem cell; progenitor cell; differentiation; astrocyte; pituitary adenylate cyclase-activating polypeptide;

D O I：

10.1007/4-431-28775-2_8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recently it has been reported that pituitary adenylate cyclase-activating polypeptide (PACAP) possesses diverse physiological functions in central nervous system. In this study, the effect of physiological concentrations of PACAP on the differentiation of neural stem cells is described. When neural stem cells were exposed to 0.2 nM PACAP, total number of the cells decreased during the 8 days-culture. However, number of MAP2-immunopositive cells decreased while GFAP-immunopositive cells increased depending on the concentration of PACAP (0.2-2 nM). Neural stem cells were differentiated into astrocytes even at a concentration below 2 nM. These results indicate that PACAP at a low concentration prefers induction of differentiation into astrocytes rather than proliferation in neural stem cells.

引用

页码：57 / +

页数：3

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