The synthesis of 6,6-difluoroshikimic acid

被引：14

作者：

Humphreys, JL ^{[1
]}

Lowes, DJ ^{[1
]}

Wesson, KA ^{[1
]}

Whitehead, RC ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2004.03.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 6.6-difluoroshikimic acid (4) has been achieved in nine Steps from the enantiopure diol 9, which is derived from microbial dihydroxylation of iodobenzene. The synthetic strategy has also been demonstrated to be applicable to the preparation of other 6-substituted anologues of shikimic acid. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3429 / 3432

页数：4

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