Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment

被引：74

作者：

Frasch, H. Frederick ^{[1
]}

Dotson, G. Scott ^{[2
]}

Bunge, Annette L. ^{[3
]}

Chen, Chen-Peng ^{[4
]}

Cherrie, John W. ^{[5
]}

Kasting, Gerald B. ^{[6
]}

Kissel, John C. ^{[7
]}

Sahmel, Jennifer ^{[8
]}

Semple, Sean ^{[9
]}

Wilkinson, Simon ^{[10
]}

机构：

[1] NIOSH, Hlth Effects Lab, Morgantown, WV 26505 USA

[2] NIOSH, Educ & Informat Div, Cincinnati, OH USA

[3] Colorado Sch Mines, Dept Chem & Biol Engn, Golden, CO 80401 USA

[4] China Med Univ, Coll Publ Hlth, Dept Occupat Safety & Hlth, Taichung, Taiwan

[5] Inst Occupat Med, Edinburgh EH8 9SV, Midlothian, Scotland

[6] Univ Cincinnati, Winkle Coll Pharm, Cincinnati, OH USA

[7] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[8] ChemRisk, Boulder, CO USA

[9] Univ Aberdeen, Div Appl Hlth Sci, Aberdeen, Scotland

[10] Univ Newcastle, Med Toxicol Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

来源：

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY | 2014年 / 24卷 / 01期

关键词：

risk assessment; skin absorption; percent absorption; fractional absorption; dermal load; maximum flux; evaporation; SKIN IN-VITRO; PERCUTANEOUS-ABSORPTION; VOLATILE COMPOUNDS; KINETICS; SOLVENTS;

D O I：

10.1038/jes.2013.23

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.

引用

页码：65 / 73

页数：9

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