Pd-Catalyzed Chemoselective Catellani Ortho-Arylation of Iodopyrroles: Rapid Total Synthesis of Rhazinal

被引：99

作者：

Sui, Xianwei ^{[1
]}

Zhu, Rui ^{[1
]}

Li, Gencheng ^{[1
]}

Ma, Xinna ^{[1
]}

Gu, Zhenhua ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 25期

基金：

中国国家自然科学基金;

关键词：

TETRASUBSTITUTED HELICAL ALKENES; H BOND ACTIVATION; CONCISE SYNTHESIS; ARYL IODIDES; PALLADIUM; ALKYLATION; HETEROCYCLES; INDOLES; ANNULATION; SEQUENCE;

D O I：

10.1021/ja404494u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pd-catalyzed chemoselective Catellani reaction of iodopyrroles was developed. The rare chemoselectivity between two,different aryl halides was realized by optimizing the kinetics of the different steps of this multicomponent process. The new developed method led to the rapid synthesis of rhazinal in a highly efficient manner.

引用

页码：9318 / 9321

页数：4

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