DNA microarray analysis of hepatic gene expression in mice exposed to cadmium for 30 days

被引：3

作者：

Tokumoto, Maki ^{[1
,2
]}

Ohtsu, Tomoaki ^{[3
]}

Imai, Shunji ^{[3
]}

Honda, Akiko ^{[3
,4
]}

Nagase, Hisamitsu ^{[3
]}

Satoh, Masahiko ^{[2
]}

机构：

[1] Showa Pharmaceut Univ, Lab Chem Toxicol & Environm Hlth, Machida, Tokyo 1948543, Japan

[2] Aichi Gakuin Univ, Sch Pharm, Lab Pharmaceut Hlth Sci, Chikusa Ku, Nagoya, Aichi 4648650, Japan

[3] Gifu Pharmaceut Univ, Lab Hyg Chem & Mol Toxicol, Gifu 5011196, Japan

[4] Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Div Environm Hlth,Nishikyo Ku, Kyoto 6158540, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2013年 / 38卷 / 01期

关键词：

Cadmium; Liver; DNA microarray; LIVER; KIDNEY; RAT;

D O I：

10.2131/jts.38.155

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Although cadmium causes hepatotoxicity, its molecular mechanism is unclear. In the present study, transcriptional responses in the liver of C57BL/6J mice given 50 ppm cadmium as a drinking water for 30 days were evaluated with DNA microarray. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were not elevated following the administration of cadmium. Cadmium increased the expressions of 2 genes and reduced those of 15 genes in the liver of mice before the leading to hepatotoxicity.

引用

页码：155 / 157

页数：3

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