Evidence for novel genetic loci associated with metabolic traits in Yup'ik people

被引：10

作者：

Aslibekyan, Stella ^{[1
]}

Vaughan, Laura Kelly ^{[2
]}

Wiener, Howard W. ^{[1
]}

Lemas, Dominick J. ^{[3
]}

Klimentidis, Yann C. ^{[4
]}

Havel, Peter J. ^{[5
,6
]}

Stanhope, Kimber L. ^{[5
,6
]}

O'brien, Diane M. ^{[7
]}

Hopkins, Scarlett E. ^{[7
]}

Boyer, Bert B. ^{[7
]}

Tiwari, Hemant K. ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Sect Stat Genet, Dept Biostat, Birmingham, AL 35294 USA

[3] Univ Colorado, Dept Pediat, Aurora, CO 80045 USA

[4] Univ Arizona, Epidemiol & Biostat Div, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ 85724 USA

[5] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[6] Univ Calif Davis, Dept Mol Biosci, Davis, CA 95616 USA

[7] Univ Alaska Fairbanks, Inst Arctic Biol, Ctr Alaska Native Hlth Res, Fairbanks, AK 99775 USA

来源：

AMERICAN JOURNAL OF HUMAN BIOLOGY | 2013年 / 25卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NATIVE HEALTH RESEARCH; ALASKAN ESKIMOS; LIPID LEVELS; LINKAGE; RISK; POLYMORPHISMS; PEDIGREES; GENOTYPE; DISEASE; OBESITY;

D O I：

10.1002/ajhb.22429

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Objectives: To identify genomic regions associated with fasting plasma lipid profiles, insulin, glucose, and glycosylated hemoglobin in a Yup'ik study population, and to evaluate whether the observed associations between genetic factors and metabolic traits were modified by dietary intake of marine derived omega-3 polyunsaturated acids (n-3 PUFA). Methods: A genome-wide linkage scan was conducted among 982 participants of the Center for Alaska Native Health Research study. n-3 PUFA intake was estimated using the nitrogen stable isotope ratio (N-15) of erythrocytes. All genotyped SNPs located within genomic regions with LOD scores>2 were subsequently tested for individual SNP associations with metabolic traits using linear models that account for familial correlation as well as age, sex, community group, and n-3 PUFA intake. Separate linear models were fit to evaluate interactions between the genotype of interest and n-3 PUFA intake. Results: We identified several chromosomal regions linked to serum apolipoprotein A2, high density lipoprotein-, low density lipoprotein-, and total cholesterol, insulin, and glycosylated hemoglobin. Genetic variants found to be associated with total cholesterol mapped to a region containing previously validated lipid loci on chromosome 19, and additional novel peaks of biological interest were identified at 11q12.2-11q13.2. We did not observe any significant interactions between n-3 PUFA intake, genotypes, and metabolic traits. Conclusions: We have completed a whole genome linkage scan for metabolic traits in Native Alaskans, confirming previously identified loci, and offering preliminary evidence of novel loci implicated in chronic disease pathogenesis in this population. Am. J. Hum. Biol., 25:673-680, 2013. (c) 2013 Wiley Periodicals, Inc.

引用

页码：673 / 680

页数：8