Acylhydrazide Schiff Bases: Synthesis and Antiglycation Activity

被引：0

作者：

Khan, Khalid Mohammed ^{[1
]}

Taha, Muhammad ^{[1
,2
]}

Rahim, Fazal ^{[1
,3
]}

Fakhri, Muhammad Imran ^{[1
]}

Jamil, Waqas ^{[1
,4
]}

Khan, Momin ^{[1
,5
]}

Rasheed, Saima ^{[1
]}

Karim, Aneela ^{[1
]}

Perveen, Shahnaz

Choudhary, Mohammad Iqbal ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[2] Univ Teknol MARA UiTM, Atta ur Rahman Inst Nat Prod Discovery, Bandar Puncak Alam 42300, Selangor, Malaysia

[3] Hazara Univ, Dept Chem, Mansehra, Pakistan

[4] Univ Sindh, Inst Adv Res Studies Chem Sci, Jamshoro, Pakistan

[5] Abdul Wali Khan Univ, Dept Chem, Mardan 23200, Khyber Pakhtunk, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 03期

关键词：

Acylhydrazide Schiff bases; antiglycation; AGEs; ADVANCED GLYCATION ENDPRODUCTS; IN-VITRO; ANTIPLATELET PROPERTIES; HYDRAZONE DERIVATIVES; END-PRODUCT; INHIBITORS; COMPLICATIONS; ANTIFUNGAL; ANALOGS; AGENTS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 +/- 10.6 mu M), 27 (IC50 = 234.83 +/- 10.28 mu M), 2 (IC50 = 240.99 +/- 4.2 mu M), and 14 (IC50 = 276.2 +/- 2.3 mu M) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 +/- 1.5 mu M). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.

引用

页码：929 / 937

页数：9

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