Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study

被引：16

作者：

Sameer, Aga Syed ^{[1
]}

Parray, Fazl Q. ^{[1
]}

Dar, Manzoor Ahmad ^{[1
]}

Nissar, Saniya ^{[1
]}

Banday, Mujeeb Zafar ^{[1
]}

Rasool, Sabha ^{[1
]}

Gulzar, G. M. ^{[1
]}

Chowdri, Nissar A. ^{[1
]}

Siddiqi, Mushtaq A. ^{[1
]}

机构：

[1] Transworld Muslim Univ, Srinagar 190005, Kashmir, India

来源：

MOLECULAR MEDICINE REPORTS | 2013年 / 7卷 / 03期

关键词：

colorectal cancer; cyclin D1; polymorphism; Kashmir; SQUAMOUS-CELL CARCINOMA; A870G POLYMORPHISM; D1; POLYMORPHISM; CERVICAL-CANCER; OVEREXPRESSION; EXPRESSION; CCND1; PROGNOSIS; SUSCEPTIBILITY; AMPLIFICATION;

D O I：

10.3892/mmr.2013.1287

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population. The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison with 160 healthy controls was investigated. No direct significant association between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population.

引用

页码：811 / 815

页数：5

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