Circular RNAs: splicing's enigma variations

被引：410

作者：

Hentze, Matthias W. ^{[1
]}

Preiss, Thomas ^{[2
]}

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Australian Natl Univ, John Curtin Sch Med Res, Genome Biol Dept, Canberra, ACT 2601, Australia

来源：

EMBO JOURNAL | 2013年 / 32卷 / 07期

关键词：

D O I：

10.1038/emboj.2013.53

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circular (circ) RNAs are to transcriptomics what the famous hidden musical theme is to Elgar's Enigma Variations: woven into the entire composition but not unambiguously identified or understood by scholars to this day. Now, two studies (Hansen et al, 2013; Memczak et al, 2013) have made substantial progress in both, identifying thousands of circRNAs and beginning to crack the enigma of their cellular function, by demonstrating that the circRNAs CiRS-7/CDR1as and SRY function as natural and highly stable sponges for specific microRNAs.

引用

页码：923 / 925

页数：3

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