Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses

被引：33

作者：

Botta, Giorgia ^{[1
]}

Bizzarri, Bruno Mattia ^{[1
]}

Garozzo, Adriana ^{[2
]}

Timpanaro, Rossella ^{[2
]}

Bisignano, Benedetta ^{[2
]}

Amatore, Donatella ^{[3
,4
]}

Palamara, Anna Teresa ^{[3
,4
]}

Nencioni, Lucia ^{[3
]}

Saladino, Raffaele ^{[1
]}

机构：

[1] Univ Tuscia, Dept Ecol & Biol, I-01100 Viterbo, VT, Italy

[2] Univ Catania CT, Microbiol Sect, Dept Biomed & Biotechnol Sci, I-95124 Catania, Italy

[3] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[4] Telemat Univ, IRCCS San Raffaele Pisana, I-00166 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2015年 / 23卷 / 17期

关键词：

Antiviral activity; Catechols; Hydroxytyrosol derivatives; Dihydrocaffeoyl derivatives; DNA and RNA viruses; ROSMARINIC ACID; ANTIOXIDANT; DERIVATIVES; OIL; REPLICATION; INHIBITION; ACTIVATION; BEHAVIOR; SERIES;

D O I：

10.1016/j.bmc.2015.07.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant antiviral activity was observed in the inhibition of HSV-1, HSV-2, Cox B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 infection. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5345 / 5351

页数：7

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