Access of cis-4-monofluoromethyl-1,3-oxazolidines via a formal [3+2] cycloaddition triggered by BF3•OEt2

被引：1

作者：

Sato, Keiichi ^{[1
]}

Yamada, Yasunori ^{[1
]}

Hanamoto, Takeshi ^{[1
]}

机构：

[1] Saga Univ, Dept Chem & Appl Chem, Honjyo Machi 1, Saga 8408502, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2020年 / 237卷

关键词：

Organofluorine; Monofluoromethyl group (CFH2); Aziridine; Oxazolidine; Cycloaddition; ONE-POT SYNTHESIS; 2-TRIFLUOROMETHYL-N-TOSYLAZIRIDINE; AZIRIDINE; FLUORINE;

D O I：

10.1016/j.jfluchem.2020.109599

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of cis-4-monofluoromethyl-1,3-oxazolidines were prepared from 2-monofluoromethyl-N-tosylaziridine and various aldehydes in the presence of (BF3OEt2)-O-center dot under mild conditions. The high regioselectivity of the reaction suggested that the electron-withdrawing ability of the monofluoromethyl group is similar to that of trifluoromethyl and difluoromethyl groups in this type of cycloaddition.

引用

页数：6

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