synbreed: a framework for the analysis of genomic prediction data using R

被引:225
作者
Wimmer, Valentin [1 ]
Albrecht, Theresa [1 ]
Auinger, Hans-Juergen [1 ]
Schoen, Chris-Carolin [1 ]
机构
[1] Tech Univ Munich, D-85354 Freising Weihenstephan, Germany
关键词
D O I
10.1093/bioinformatics/bts335
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present a novel R package named synbreed to derive genome-based predictions from high-throughput genotyping and large-scale phenotyping data. The package contains a comprehensive collection of functions required to fit and cross-validate genomic prediction models. All functions are embedded within the framework of a single, unified data object. Thereby a versatile genomic prediction analysis pipeline covering data processing, visualization and analysis is established within one software package. The implementation is flexible with respect to a wide range of data formats and models. The package fills an existing gap in the availability of user-friendly software for next-generation genetics research and education.
引用
收藏
页码:2086 / 2087
页数:2
相关论文
共 10 条
[1]   Genome-based prediction of testcross values in maize [J].
Albrecht, Theresa ;
Wimmer, Valentin ;
Auinger, Hans-Juergen ;
Erbe, Malena ;
Knaak, Carsten ;
Ouzunova, Milena ;
Simianer, Henner ;
Schoen, Chris-Carolin .
THEORETICAL AND APPLIED GENETICS, 2011, 123 (02) :339-350
[2]  
[Anonymous], 2012, R LANG ENV STAT COMP
[3]   R/qtl: QTL mapping in experimental crosses [J].
Broman, KW ;
Wu, H ;
Sen, S ;
Churchill, GA .
BIOINFORMATICS, 2003, 19 (07) :889-890
[4]   A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals [J].
Browning, Brian L. ;
Browning, Sharon R. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (02) :210-223
[5]  
Clifford D., 2012, REGRESS PACKAGE R PA
[6]  
Gilmore A.R., 2009, Asreml User Guide Release 3.0
[7]   The impact of genetic relationship information on genome-assisted breeding values [J].
Habier, D. ;
Fernando, R. L. ;
Dekkers, J. C. M. .
GENETICS, 2007, 177 (04) :2389-2397
[8]  
Meuwissen THE, 2001, GENETICS, V157, P1819
[9]   Genomic-Enabled Prediction Based on Molecular Markers and Pedigree Using the Bayesian Linear Regression Package in R [J].
Perez, Paulino ;
de los Campos, Gustavo ;
Crossa, Jose ;
Gianola, Daniel .
PLANT GENOME, 2010, 3 (02) :106-116
[10]   PLINK: A tool set for whole-genome association and population-based linkage analyses [J].
Purcell, Shaun ;
Neale, Benjamin ;
Todd-Brown, Kathe ;
Thomas, Lori ;
Ferreira, Manuel A. R. ;
Bender, David ;
Maller, Julian ;
Sklar, Pamela ;
de Bakker, Paul I. W. ;
Daly, Mark J. ;
Sham, Pak C. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (03) :559-575