Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease

被引：321

作者：

Hao, Changlong ^{[1
,2
]}

Qu, Aihua ^{[1
,2
]}

Xu, Liguang ^{[1
,2
]}

Sun, Maozhong ^{[1
,2
]}

Zhang, Hongyu ^{[1
,2
]}

Xu, Chuanlai ^{[1
,2
]}

Kuang, Hua ^{[1
,2
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, Int Joint Res Lab Biointerface & Biodetect, Wuxi 214122, Jiangsu, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 02期

基金：

中国国家自然科学基金;

关键词：

NANOZYME; CELLS; MECHANISMS; GENERATION; COPPER; METAL;

D O I：

10.1021/jacs.8b11856

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform CuxO nanoparticle clusters (NCs) with an average size of 65 +/- 7 nm, using phenylalanine (Phe) as the structure-directing agent. These CuxO NCs functionally mimicked the activities of peroxidase, superoxide dismutase, catalase, and glutathione peroxidase. Because they eliminated ROS, the CuxO NCs inhibited neurotoxicity in a cellular model of Parkinson's disease and rescued the memory loss of mice with Parkinson's disease. The biocompatibility and multiple enzyme-mimicking activities of CuxO NCs offer new opportunities for the application of NCs in biomedicine, biosensing, and biocatalysis.

引用

页码：1091 / 1099

页数：9

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