Low doses of recombinant erythropoietin in the treatment of renal anemia in patients on chronic hemodialysis and ambulatory peritoneal dialysis

被引：0

作者：

Lashutin, SV ^{[1
]}

Nikolaev, AY ^{[1
]}

Ermolenko, VM ^{[1
]}

Shutov, EV ^{[1
]}

Bezruk, VG ^{[1
]}

Ivaschenko, MA ^{[1
]}

机构：

[1] IM Sechenov Med Acad, Dept Nephrol, Moscow, Russia

来源：

TERAPEVTICHESKII ARKHIV | 1999年 / 71卷 / 06期

关键词：

anemia; hemodialysis; peritoneal dialysis; preparations of recombinant human erythropoietin;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. A comparative study of efficiency and safety of low-dose erythropoietin (EP) in two groups of patients with chronic renal failure (CRF): patients on chronic hemodialysis (CHD) and patients on continuous ambulatory hemodialysis (CAHD). Materials and methods. 51 CRF adult patients with renal anemia on hemodialysis entered the trial: 34 CHD and 17 CAHD patients EP compounds were injected s.c. in a dose 1000-2000 U 2-3 times a week. Results. EP treatment provided a rapid correction of renal anemia in the majority of patients. After 3-month EP therapy a mean increment of Hct (Hct delta) was much greater (p < 0.05) in CAHD than CHD patients (12.2 +/- 6.0 and 9.0 +/- 5.1%, respectively), though EP dose were the same in both the groups. Conclusion. Low doses of recombinant human EP injected subcutaneously were effective and safe for correction of anemia in both CHD and CAHD. In CAHD patients EP effectiveness was much higher than in CHD patients.

引用

页码：61 / 63

页数：3

共 14 条

[1]

ALMOND MK, 1994, NEPHROL DIAL TRANSPL, V9, P270

[2]

BALASKAS EV, 1993, PERITON DIAL INT S2, V13, P553

[3] INTRAPERITONEAL PRODUCTION OF ERYTHROPOIETIN WITH CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS [J].