A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment

被引：8

作者：

Gala, Dhir ^{[1
]}

Scharf, Shelbie ^{[1
]}

Kudlak, Megan ^{[1
]}

Green, Christian ^{[1
]}

Khowaja, Faisal ^{[1
]}

Shah, Mili ^{[1
]}

Kumar, Vikash ^{[2
]}

Ullal, Gautam ^{[3
]}

机构：

[1] Amer Univ Caribbean Sch Med, 1 Univ Dr & Jordan Dr, Sint Maarten, Netherlands

[2] Brooklyn Hosp Ctr, Dept Internal Med, 121 DeKalb Ave, Brooklyn, NY 11201 USA

[3] Amer Univ Caribbean Sch Med, Dept Neurosci, 1 Univ Dr & Jordan Dr, Sint Maarten, Netherlands

来源：

DISEASES | 2022年 / 10卷 / 04期

关键词：

celiac disease; neurological manifestations; epilepsy; headache; neuropathy; GLUTEN-FREE DIET; LARAZOTIDE ACETATE; INCREASED RISK; DERMATITIS-HERPETIFORMIS; COGNITIVE IMPAIRMENT; MOLECULAR MIMICRY; GLIADIN PEPTIDES; ENZYME THERAPY; DOUBLE-BLIND; T-CELLS;

D O I：

10.3390/diseases10040111

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause.

引用

页数：14

共 131 条

[1] Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet:: A longitudinal study [J].