Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis

被引：18

作者：

Kaieda, Shinjiro ^{[1
]}

Yoshida, Naomi ^{[1
]}

Yamashita, Fumiya ^{[1
]}

Okamoto, Masaki ^{[1
]}

Ida, Hiroaki ^{[1
]}

Hoshino, Tomoaki ^{[1
]}

Fukuda, Takaaki ^{[2
]}

机构：

[1] Kurume Univ, Sch Med, Div Respirol Neurol & Rheumatol, Dept Med, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Med Ctr, Ctr Rheumat Dis, Kurume, Fukuoka 8300011, Japan

来源：

MODERN RHEUMATOLOGY | 2015年 / 25卷 / 06期

关键词：

Dermatomyositis; Hypercytokinemia; Macrophage activation syndrome; Plasma exchange; Tacrolimus; REACTIVE HEMOPHAGOCYTIC SYNDROME; JUVENILE IDIOPATHIC ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SOLUBLE INTERLEUKIN-2-RECEPTOR; CLINICAL-FEATURES; STILLS-DISEASE; LYMPHOHISTIOCYTOSIS; TACROLIMUS; EFFICACY; CYCLOSPORINE;

D O I：

10.3109/14397595.2013.844402

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchange therapy was effective in this case for treating MAS. This combination therapy is especially useful for MAS refractory to steroids.

引用

页码：962 / 966

页数：5

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