Effect of MUC8 on Airway Inflammation: A Friend or a Foe?

被引：7
作者：
Cha, Hee-Jae [1 ]
Song, Kyoung Seob [2 ]
机构：
[1] Kosin Univ, Coll Med, Dept Parasitol & Genet, 34 Amnam Dong, Busan 49267, South Korea
[2] Kosin Univ, Dept Physiol, Coll Med, 34 Amnam Dong, Busan 49267, South Korea
来源：
JOURNAL OF CLINICAL MEDICINE | 2018年 / 7卷 / 02期
关键词：
MUC8; airway inflammation; inflammatory cytokines; mucus hypersecretion/overproduction; negative regulator; ACTIVATED PROTEIN-KINASE; ELEMENT-BINDING PROTEIN; EPITHELIAL-CELLS; GENE-EXPRESSION; P38; MAPK; UP-REGULATION; MUC5AC; HYPERSECRETION; ORGANIZATION; SECRETION;
D O I：
10.3390/jcm7020026
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review, we compile identifying molecular mechanisms of MUC8 gene expression and studies characterizing the physiological functions of MUC8 in the airway and analyzing how altered MUC8 gene expression in the lung is affected by negative regulators.
引用
收藏
页数：5
相关论文
共 25 条
  • [1] Bae CH, 2014, CLIN EXP OTORHINOLAR, V7, P198
  • [2] Insulin-like growth factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells
    Bae, Chang Hoon
    Kim, Jung Soo
    Song, Si-Youn
    Kim, Yong-Woon
    Park, So-Young
    Kim, Yong-Dae
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 430 (02) : 683 - 688
  • [3] A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia
    Button, Brian
    Cai, Li-Heng
    Ehre, Camille
    Kesimer, Mehmet
    Hill, David B.
    Sheehan, John K.
    Boucher, Richard C.
    Rubinstein, Michael
    [J]. SCIENCE, 2012, 337 (6097) : 937 - 941
  • [4] Silencing of MUC8 by siRNA increases P2Y2-induced airway inflammation
    Cha, Hee-Jae
    Jung, Min-Su
    Ahn, Do Whan
    Choi, Jang-Kyu
    Ock, Mee Sun
    Kim, Kyung Soo
    Yoon, Joo-Heon
    Song, Eun Ju
    Song, Kyoung Seob
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2015, 308 (06) : L495 - L502
  • [5] Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells
    Cho, KN
    Choi, JY
    Kim, CH
    Baek, SJ
    Chung, KC
    Moon, UY
    Kim, RS
    Lee, WJ
    Koo, JS
    Yoon, JH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (08) : 6676 - 6681
  • [6] Asian sand dust increases MUC8 and MUC5B expressions via TLR4-dependent ERK2 and p38 MAPK in human airway epithelial cells
    Choi, Yoon Seok
    Bae, Chang Hoon
    Song, Si-Youn
    Kim, Yong-Dae
    [J]. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2015, 29 (03) : 161 - 165
  • [7] Mucus hypersecretion in asthma: causes and effects
    Evans, Christopher M.
    Kim, Kyubo
    Tuvim, Michael J.
    Dickey, Burton F.
    [J]. CURRENT OPINION IN PULMONARY MEDICINE, 2009, 15 (01) : 4 - 11
  • [8] Airway mucus: The good, the bad, the sticky
    Evans, Christopher M.
    Koo, Ja Seok
    [J]. PHARMACOLOGY & THERAPEUTICS, 2009, 121 (03) : 332 - 348
  • [9] Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells
    Finkbeiner, Walter E.
    Zlock, Lorna T.
    Morikawa, Masatoshi
    Lao, Anna Y.
    Dasari, Vijay
    Widdicombe, Jonathan H.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2011, 301 (04) : L402 - L414
  • [10] Organization and regulation of mitogen-activated protein kinase signaling pathways
    Garrington, TP
    Johnson, GL
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) : 211 - 218
123