Disturbed XIAP and XAF1 Expression Balance Is an Independent Prognostic Factor in Gastric Adenocarcinomas

被引：44

作者：

Shibata, Tomotaka ^{[1
]}

Noguchi, Tsuyoshi ^{[2
]}

Takeno, Shinsuke ^{[1
]}

Gabbert, Helmut E. ^{[3
]}

Ramp, Uwe ^{[3
]}

Kawahara, Katsunobu ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Oncol Sci Surg 2, Oita 8795593, Japan

[2] Oita Univ, Oita Univ Hosp, Dept Surg Gastroenterol, Oita 87011, Japan

[3] Univ Dusseldorf, Inst Pathol, D-4000 Dusseldorf, Germany

来源：

ANNALS OF SURGICAL ONCOLOGY | 2008年 / 15卷 / 12期

关键词：

D O I：

10.1245/s10434-008-0062-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified: second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI (Smac/DIABLO) and XIAP-associated factor 1 (XAF1). However, little research has been conducted on the association between gastric cancer survival and the mechanism of apoptosis involving XIAP and its antagonists, Smac/DIABLO and XAF1. Methods: XIAP, Smac/DIABLO, and XAF1 expression was analyzed by immunohistochemistry (IHC) in 187 gastric adenocarcinomas. Correlations between XIAP, Smac/DIABLO or XAF1 expression and clinicopathological factors were analyzed. Disease-specific survival after surgery was examined. Results: Of 187 samples, XIAP was overexpressed in 140, Smac was overexpressed in 117, and XAF1 was overexpressed in 106. Individually, XIAP, Smac, and XAF1 were not significantly associated with disease-specific survival. However, patients showing high expression of XIAP and low expression of XAF1 had significantly poorer survival when compared with other groups (P = 0.024). Conclusion: The expression balance of XIAP and XAF1 is an independent prognostic factor in gastric adenocarcinoma.

引用

页码：3579 / 3587

页数：9

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