Applications of magnetotactic bacteria and magnetosome for cancer treatment: A review emphasizing on practical and mechanistic aspects

被引：37

作者：

Alphandery, Edouard ^{[1
,2
,3
]}

机构：

[1] Paris Sorbonne Univ, Museum Natl Hist Nat, Inst Mineral Phys Mat & Cosmochim, CNRS,IRD,IMPMC,UMR 7590, F-75005 Paris, France

[2] Nanobacterie SARL, 36 Blvd Flandrin, F-75116 Paris, France

[3] UZH Univ Zurich, Inst Anat, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2020年 / 25卷 / 08期

关键词：

MAGNETOSPIRILLUM-GRYPHISWALDENSE MSR-1; MAGNETIC NANOPARTICLES; CO-DELIVERY; GROWTH; MICE; GLIOBLASTOMA; DOXORUBICIN; BYSTANDER; ENDOTOXIN; THERAPY;

D O I：

10.1016/j.drudis.2020.06.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Magnetotactic bacteria (MTB) synthesize iron oxide (Fe3O4) nanoparticles (NPs), called magnetosomes, with large sizes leading to a ferrimagnetic behavior and a stable magnetic moment at physiological temperature, a chain structure that prevents NP aggregation and promotes uniform NP distribution, and a mineral core of magnetite/maghemite composition, which can be stabilized by an organic coating. Such properties can favor magnetosome administration to humans under certain optimized non-toxic conditions of fabrication. In this review, I describe the fabrication methods, physico-chemical properties, and the anti-tumor activity of different types of MTB/magnetosome preparations, highlighting the bio-compatibility and excellent anti-tumor activity of purified non-pyrogenic magnetosome minerals stabilized by a synthetic chemical compound.

引用

页码：1444 / 1452

页数：9

共 52 条

[1] Yield cultivation of magnetotactic bacteria and magnetosomes: A review [J].

Ali, Imran ;

Peng, Changsheng ;

Khan, Zahid M. ;

Naz, Iffat .

JOURNAL OF BASIC MICROBIOLOGY, 2017, 57 (08) :643-652

[2]

Alphande E., US patent appl, Patent No. [15/510048., 15510048]

[3] Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field [J].

Alphandery, Edouard ;

Idbaih, Ahmed ;

Adam, Clovis ;

Delattre, Jean-Yves ;

Schmitt, Charlotte ;

Guyot, Francois ;

Chebbi, Imene .

JOURNAL OF CONTROLLED RELEASE, 2017, 262 :259-272

[4] Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia [J].

Alphandery, Edouard ;

Idbaih, Ahmed ;

Adam, Clovis ;

Delattre, Jean-Yves ;

Schmitt, Charlotte ;

Guyot, Francois ;

Chebbi, Imene .

BIOMATERIALS, 2017, 141 :210-222

[5] Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy [J].

Alphandery, Edouard ;

Faure, Stephanie ;

Seksek, Olivier ;

Guyot, Francois ;

Chebbi, Imene .

ACS NANO, 2011, 5 (08) :6279-6296

[6] Formation of magnetite by bacteria and its application [J].

Arakaki, Atsushi ;

Nakazawa, Hidekazu ;

Nemoto, Michiko ;

Mori, Tetsushi ;

Matsunaga, Tadashi .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2008, 5 (26) :977-999

[7] Magnetosome formation in prokaryotes [J].

Bazylinski, DA ;

Frankel, RB .

NATURE REVIEWS MICROBIOLOGY, 2004, 2 (03) :217-230

[8] Visualizing Implanted Tumors in Mice with Magnetic Resonance Imaging Using Magnetotactic Bacteria [J].

Benoit, Michael R. ;

Mayer, Dirk ;

Barak, Yoram ;

Chen, Ian Y. ;

Hu, Wei ;

Cheng, Zhen ;

Wang, Shan X. ;

Spielman, Daniel M. ;

Gambhir, Sanjiv S. ;

Matin, A. .

CLINICAL CANCER RESEARCH, 2009, 15 (16) :5170-5177

[9] A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media [J].

Berny, Clement ;

Le Fevre, Raphael ;

Guyot, Francois ;

Blondeau, Karine ;

Guizonne, Christine ;

Rousseau, Emilie ;

Bayan, Nicolas ;

Alphandery, Edouard .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8

[10] Genetically tailored magnetosomes used as MRI probe for molecular imaging of brain tumor [J].

Boucher, M. ;

Geffroy, F. ;

Preveral, S. ;

Bellanger, L. ;

Selingue, E. ;

Adryanczyk-Perrier, G. ;

Pean, M. ;

Lefevre, C. T. ;

Pignol, D. ;

Ginet, N. ;

Meriaux, S. .

BIOMATERIALS, 2017, 121 :167-178

← 1 2 3 4 5 6 →