Primary antibiotic resistance of Helicobacter pylori among a Chinese Tibetan population

被引：14
作者：
Tang, Xiaoqiong [1 ]
Chen, Xiaohong [2 ]
Shen, Yalin [1 ]
Yang, Tiankuo [1 ]
Hu, Renwei [3 ]
Debowski, Aleksandra W. [4 ,5 ]
Stubbs, Keith A. [5 ]
Benghezal, Mohammed [1 ]
Marshall, Barry J. [4 ]
Li, Hong [1 ]
Tang, Hong [1 ]
机构：
[1] Sichuan Univ, Ctr Infect Dis, West China Hosp, West China Marshall Res Ctr Infect Dis, Chengdu 610041, Peoples R China
[2] Hosp Chengdu Off Peoples Govt Tibetan Autonomous, Dept Digest Med, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu 610041, Peoples R China
[4] Univ Western Australia, Helicobacter Pylori Res Lab, Sch Biomed Sci, Marshall Ctr Infect Dis Res & Training, Nedlands, WA 6009, Australia
[5] Univ Western Australia, Sch Mol Sci, Crawley 6009, Australia
来源：
FUTURE MICROBIOLOGY | 2020年 / 15卷 / 14期
基金：
中国国家自然科学基金;
关键词：
antimicrobial susceptibility testing; empiric therapy; Helicobacter pylori; rifampicin; Tibetan population; AGAR DILUTION METHOD; QUADRUPLE THERAPIES; CLARITHROMYCIN; METRONIDAZOLE; BISMUTH; INFECTION; CONSENSUS;
D O I：
10.2217/fmb-2020-0206
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To evaluate the primary antibiotic resistance in Helicobacter pyloristrains isolated from a Chinese Tibetan population. Methods & materials: Gastric biopsies from 400 H. pyloritreatment-naive Tibetan patients were collected for H. pylori isolation. Susceptibility to amoxicillin (AML)/clarithromycin (CLR)/levofloxacin (LEV)/metronidazole (MTZ)/tetracycline (TET)/rifampicin (RIF)/furazolidone (FZD) was determined by E-test or a disk diffusion assay. Results:Biopsies from 117 patients wereH. pyloriculture positive (29.3%). The primary resistance rates to MTZ, CLR, LEV, RIF, AML, TET and FZD were 90.6, 44.4, 28.2, 69.2, 7.7, 0.8 and 0.8%, respectively. Interestingly, 42.7% of the strains had simultaneous resistance to CLR and MTZ. Conclusion: Among Tibetan strains, primary resistance rates were high for CLR/MTZ/LEV, whereas primary resistance rates to AML/TET/FZD were low. The high resistance to RIF is a concerning finding.
引用
收藏
页码：1353 / 1361
页数：9
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