Sphingosine Kinase 1 Serves as a Pro-Viral Factor by Regulating Viral RNA Synthesis and Nuclear Export of Viral Ribonucleoprotein Complex upon Influenza Virus Infection
被引:67
作者:
Seo, Young-Jin
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机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Seo, Young-Jin
[1
,2
]
Pritzl, Curtis J.
论文数: 0引用数: 0
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机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Pritzl, Curtis J.
[1
,2
]
Vijayan, Madhuvanthi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Vijayan, Madhuvanthi
[1
,2
]
Bomb, Kavita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Bomb, Kavita
[1
,2
]
McClain, Mariah E.
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机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
McClain, Mariah E.
[1
,2
]
Alexander, Stephen
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h-index: 0
机构:
Univ Missouri, Div Biol Sci, Columbia, MO 65211 USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Alexander, Stephen
[3
]
Hahm, Bumsuk
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机构:
Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Univ Missouri, Dept Immunol, Columbia, MO USAUniv Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
Hahm, Bumsuk
[1
,2
]
机构:
[1] Univ Missouri, Dept Surg & Mol Microbiol, Columbia, MO 65211 USA
[2] Univ Missouri, Dept Immunol, Columbia, MO USA
[3] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA
Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study, we demonstrate that influenza virus increases the expression and activation of sphingosine kinase (SK) 1, which in turn regulates diverse cellular signaling pathways. Inhibition of SK suppressed virus-induced NF-kappa B activation and markedly reduced the synthesis of viral RNAs and proteins. Further, SK blockade interfered with activation of Ran-binding protein 3 (RanBP3), a cofactor of chromosome region maintenance 1 (CRM1), to inhibit CRM1-mediated nuclear export of the influenza viral ribonucleoprotein complex. In support of this observation, SK inhibition altered the phosphorylation of ERK, p90RSK, and AKT, which is the upstream signal of RanBP3/CRM1 activation. Collectively, these results indicate that SK is a key pro-viral factor regulating multiple cellular signal pathways triggered by influenza virus infection.
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Alvarez, Sergio E.
;
Harikumar, Kuzhuvelil B.
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h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Harikumar, Kuzhuvelil B.
;
Hait, Nitai C.
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机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Hait, Nitai C.
;
Allegood, Jeremy
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机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Allegood, Jeremy
;
Strub, Graham M.
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h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Strub, Graham M.
;
Kim, Eugene Y.
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h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Kim, Eugene Y.
;
Maceyka, Michael
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机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Maceyka, Michael
;
Jiang, Hualiang
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机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R ChinaVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Jiang, Hualiang
;
Luo, Cheng
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机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R ChinaVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Luo, Cheng
;
Kordula, Tomasz
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机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Kordula, Tomasz
;
Milstien, Sheldon
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机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Bui, M
;
Wills, EG
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机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Wills, EG
;
Helenius, A
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机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Helenius, A
;
Whittaker, GR
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机构:
Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USACornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Alvarez, Sergio E.
;
Harikumar, Kuzhuvelil B.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Harikumar, Kuzhuvelil B.
;
Hait, Nitai C.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Hait, Nitai C.
;
Allegood, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Allegood, Jeremy
;
Strub, Graham M.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Strub, Graham M.
;
Kim, Eugene Y.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Kim, Eugene Y.
;
Maceyka, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Maceyka, Michael
;
Jiang, Hualiang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R ChinaVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Jiang, Hualiang
;
Luo, Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R ChinaVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Luo, Cheng
;
Kordula, Tomasz
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Kordula, Tomasz
;
Milstien, Sheldon
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Biochem & Mol Biophys, Sch Med, Richmond, VA 23298 USA
机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Bui, M
;
Wills, EG
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Wills, EG
;
Helenius, A
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
Helenius, A
;
Whittaker, GR
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USACornell Univ, Vet Med Ctr C5141, Dept Microbiol & Immunol, Ithaca, NY 14853 USA