Persistent Complete Response After Single-agent Sunitinib Treatment in a Case of TFE Translocation Positive Relapsed Metastatic Pediatric Renal Cell Carcinoma

被引：22

作者：

Chowdhury, Tanzina ^{[2
]}

Prichard-Jones, Kathryn ^{[1
,2
]}

Sebire, Neil J. ^{[3
]}

Bier, Nelly ^{[3
]}

Cherian, Abraham ^{[4
]}

Sullivan, Maureen O. ^{[5
]}

O'Meara, Anne ^{[5
]}

Anderson, John ^{[1
,2
]}

机构：

[1] UCL Inst Child Hlth, Unit Mol Haematol & Canc Biol, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, Dept Oncol, London, England

[3] Great Ormond St Hosp Sick Children, Dept Histopathol, London, England

[4] Great Ormond St Hosp Sick Children, Dept Urol, London, England

[5] Our Ladys Hosp Sick Children, Dublin, Ireland

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2013年 / 35卷 / 01期

关键词：

renal cell carcinoma; TFE3; Xp11; sunitinib; UP-REGULATION; INHIBITION; NEOPLASMS; FUSIONS; TUMORS;

D O I：

10.1097/MPH.0b013e318266bf34

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forty percent of renal cell carcinomas (RCCs) in childhood are characterized by translocation involving transcription factor E3 (TFE3) family members. Here, we describe a case of TFE3-positive RCC in which metastatic relapse to the mediastinal lymph nodes and pulmonary nodules was treated with single-agent sunitinib, a multitargeted tyrosine inhibitor. Complete radiologic remission was achieved after only 3 courses of treatment, and surgical exploration of metastases failed to identify any residual viable disease. The published experience of sunitinib in TFE-RCC is limited, and prospective evaluation of its activity in a larger number of patients is warranted.

引用

页码：E1 / E3

页数：3

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