Clostridium difficile disease in solid organ transplant recipients: a recommended treatment paradigm

Purpose of reviewOrgan transplant recipients have an increased incidence of Clostridium difficile disease and lower clinical response rates compared with the general population. Transplant specific treatment approaches are not defined. Therefore, a review of therapeutics in the transplant population is needed.Recent findingsA literature review on the current therapies for C. difficile was performed focusing on the evidence in transplant recipients and immunosuppressed populations.SummaryTransplant patients warrant an aggressive approach to treatment. The authors propose a suggested treatment paradigm for therapy.