Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis

被引:38
作者
Androga, Grace O. [1 ]
Hart, Julie [2 ]
Foster, Niki F. [1 ,2 ]
Charles, Adrian [3 ]
Forbes, David [3 ,4 ]
Riley, Thomas V. [1 ,2 ]
机构
[1] Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA, Australia
[2] Univ Western Australia, Queen Elizabeth II Med Ctr, Dept Microbiol, PathWest Lab Med, Nedlands, WA 6009, Australia
[3] Princess Margaret Hosp Children, Subiaco, WA, Australia
[4] Univ Western Australia, Sch Paediat & Child Hlth, Crawley, WA, Australia
关键词
INFLAMMATORY-BOWEL-DISEASE; HIGH PREVALENCE; STRAINS;
D O I
10.1128/JCM.01810-15
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Large clostridial toxin-negative, binary toxin-positive (A(-) B- CDT+) strains of Clostridium difficile are almost never associated with clinically significant C. difficile infection (CDI), possibly because such strains are not detected by most diagnostic methods. We report the isolation of an A(-) B- CDT+ ribotype 033 (RT033) strain of C. difficile from a young patient with ulcerative colitis and severe diarrhea.
引用
收藏
页码:3702 / 3704
页数:3
相关论文
共 13 条
  • [1] Evaluation of the Cepheid Xpert C. difficile/Epi and Meridian Bioscience illumigene C. difficile Assays for Detecting Clostridium difficile Ribotype 033 Strains
    Androga, Grace O.
    McGovern, Alan M.
    Elliott, Briony
    Chang, Barbara J.
    Perkins, Timothy T.
    Foster, Niki F.
    Riley, Thomas V.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (03) : 973 - 975
  • [2] [Anonymous], J ANTIMICROB CHEMOTH
  • [3] Clostridium difficile infection in Europe: a hospital-based survey
    Bauer, Martijn P.
    Notermans, Daan W.
    van Benthem, Birgit H. B.
    Brazier, Jon S.
    Wilcox, Mark H.
    Rupnik, Maja
    Monnet, Dominique L.
    van Dissel, Jaap T.
    Kuijper, Ed J.
    [J]. LANCET, 2011, 377 (9759) : 63 - 73
  • [4] Clostridium difficile infection and inflammatory bowel disease
    Cojocariu, Camelia
    Stanciu, Carol
    Stoica, Oana
    Singeap, Ana Maria
    Sfarti, Catalin
    Girleanu, Irina
    Trifan, Anca
    [J]. TURKISH JOURNAL OF GASTROENTEROLOGY, 2014, 25 (06) : 603 - 610
  • [5] Eckert C., 2015, New Microbes and New Infections, V3, P12, DOI 10.1016/j.nmni.2014.10.003
  • [6] Nationwide Surveillance Study of Clostridium difficile in Australian Neonatal Pigs Shows High Prevalence and Heterogeneity of PCR Ribotypes
    Knight, Daniel R.
    Squire, Michele M.
    Riley, Thomas V.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2015, 81 (01) : 119 - 123
  • [7] Cross-Sectional Study Reveals High Prevalence of Clostridium difficile Non-PCR Ribotype 078 Strains in Australian Veal Calves at Slaughter
    Knight, Daniel R.
    Thean, Sara
    Putsathit, Papanin
    Fenwick, Stan
    Riley, Thomas V.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2013, 79 (08) : 2630 - 2635
  • [8] LAMONT JT, 1980, LANCET, V1, P381
  • [9] Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment
    Nitzan, Orna
    Elias, Mazen
    Chazan, Bibiana
    Raz, Raul
    Saliba, Walid
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (43) : 7577 - 7585
  • [10] ACTIN-SPECIFIC ADP-RIBOSYLTRANSFERASE PRODUCED BY A CLOSTRIDIUM-DIFFICILE STRAIN
    POPOFF, MR
    RUBIN, EJ
    GILL, DM
    BOQUET, P
    [J]. INFECTION AND IMMUNITY, 1988, 56 (09) : 2299 - 2306