Genetic susceptibility to Candida infections

被引:102
作者
Smeekens, Sanne P.
van de Veerdonk, Frank L.
Kullberg, Bart Jan
Netea, Mihai G. [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6525 ED Nijmegen, Netherlands
关键词
Candida albicans; primary immunodeficiencies; interferon gamma; interleukin-17; disease susceptibility; MANNOSE-BINDING LECTIN; C-TYPE LECTIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS; INVASIVE FUNGAL-INFECTION; VULVO-VAGINAL CANDIDIASIS; BLOOD-STREAM INFECTIONS; OF-FUNCTION MUTATIONS; INBORN-ERRORS; HOST-DEFENSE; CELL-DIFFERENTIATION;
D O I
10.1002/emmm.201201678
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Candida spp. are medically important fungi causing severe mucosal and life-threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susceptibility. On the one hand, severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1, STAT3 or CARD9, recently discovered as novel clinical entities. On the other hand, more common polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia. The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease, as well as to the design of novel immunotherapeutic strategies. This review is part of the review series on host-pathogen interactions. See more reviews from this series.
引用
收藏
页码:805 / 813
页数:9
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