Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)

被引：29

作者：

Eriksen, Christian Skou ^{[1
,2
,3
]}

Garde, Ellen ^{[3
,4
,5
]}

Reislev, Nina Linde ^{[3
,4
]}

Wimmelmann, Cathrine Lawaetz ^{[3
,5
]}

Bieler, Theresa ^{[1
,2
,3
,6
,7
]}

Ziegler, Andreas Kraag ^{[1
,2
,3
]}

Gylling, Anne Theil ^{[1
,2
,3
]}

Dideriksen, Kasper Juel ^{[1
,2
,3
]}

Siebner, Hartwig Roman ^{[4
,8
,9
]}

Mortensen, Erik Lykke ^{[3
,5
]}

Kjaer, Michael ^{[1
,2
,3
]}

机构：

[1] Bispebjerg Hosp, Inst Sports Med Copenhagen, Dept Orthoped Surg M, Copenhagen, Denmark

[2] Frederiksberg Univ Hosp, Inst Sports Med Copenhagen, Dept Orthoped Surg M, Copenhagen, Denmark

[3] Univ Copenhagen, Ctr Hlth Aging, Fac Hlth & Med Sci, Copenhagen, Denmark

[4] Univ Copenhagen, Hvidovre Hosp, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Copenhagen, Denmark

[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark

[6] Bispebjerg Hosp, Dept Phys & Occupat Therapy, Copenhagen, Denmark

[7] Frederiksberg Univ Hosp, Dept Phys & Occupat Therapy, Copenhagen, Denmark

[8] Bispebjerg Hosp, Dept Neurol, Copenhagen, Denmark

[9] Frederiksberg Univ Hosp, Dept Neurol, Copenhagen, Denmark

来源：

BMJ OPEN | 2016年 / 6卷 / 12期

关键词：

WHITE-MATTER MICROSTRUCTURE; X-RAY ABSORPTIOMETRY; LEG-EXTENSOR POWER; QUALITY-OF-LIFE; OLDER-ADULTS; SKELETAL-MUSCLE; BODY-COMPOSITION; CARDIORESPIRATORY FITNESS; LONGITUDINAL CHANGES; RESISTANCE EXERCISE;

D O I：

10.1136/bmjopen-2016-012951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (forcexvelocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative. The primary aim of this randomised controlled trial is to compare the efficacy of two different 1 year strength training regimens on immediate and long-lasting improvements in muscle power in retirement-age individuals. Secondary aims are to evaluate the effect on muscle strength, muscle mass, physical and cognitive function, mental wellbeing, health-related quality of life and brain morphology. Methods and analysis: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate intensity resistance training or (3) habitual physical activity (control). Changes in primary (leg extensor power) and secondary outcomes are analysed according to the intention to treat principle and per protocol at 1, 2, 4, 7 and 10 years. Ethics and dissemination: The study is expected to generate new insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer-reviewed journals, in PhD theses and at public meetings. The study is approved by the Regional Ethical Committee (Capital Region, Copenhagen, Denmark, number H-3-2014-017).

引用

页数：13