Expression of Matrix Metalloproteinase-9 in Patients with Squamous Cell Carcinoma of the Larynx

被引：0

作者：

Colovic, Zavisa ^{[1
]}

Pesutic-Pisac, Valdi ^{[2
]}

Poljak, Nikola Kolja ^{[1
]}

Racic, Goran ^{[1
]}

Cikojevic, Drasko ^{[1
]}

Kontic, Mirko ^{[1
]}

机构：

[1] Univ Split, Split Univ Hosp Ctr, ENT Dept, Split 21000, Croatia

[2] Univ Split, Split Univ Hosp Ctr, Dept Pathol, Split 21000, Croatia

来源：

COLLEGIUM ANTROPOLOGICUM | 2013年 / 37卷 / 01期

关键词：

matrix metalloproteinase-9; squamous cell carcinoma; larynx; survival; MATRIX METALLOPROTEINASES MMP-2; PLASMINOGEN-ACTIVATOR; TUMOR INVASION; HEAD; CANCER; INVASIVENESS; GELATINASE; INHIBITORS; SURVIVAL; BENIGN;

D O I：

暂无

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Aim of this study was to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma, and to assess the role of MMP-9 expression in patient survival. Study included 196 patients with squamous cell carcinoma of the larynx treated at ENT Department, Split University Hospital Centre, from January 1, 2000 till December 31, 2009. The level of MMP-9 expression showed a statistically significant correlation (p<0.001) with the disease histopathologic grade, stage, metastatic potential, recurrence potential, and survival. Kaplan-Meier curve yielded a statistically significant survival difference (p<0.001) among the three patient groups with different levels of MMP-9 expression. The survival curve clearly showed the MMP-9 expression as a predictor of survival to be significantly (p<0.001) associated with survival. In this study, MMP-9 expression as a biological marker showed a potential predictive value in laryngeal squamous cell carcinoma.

引用

页码：151 / 155

页数：5

共 50 条

[1] Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma
Gu, Zhen-Dong
Chen, Ke-Neng
Li, Ming
Gu, Jin
Li, Ji-You
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (06) : 871 - 874
[2] Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma
Zhen-Dong Gu
World Journal of Gastroenterology, 2005, (06) : 871 - 874
[3] EXPRESSION OF MATRIX METALLOPROTEINASE-9 IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL PSEUDOEPITHELIOMATOUS HYPERPLASIA
Awan, Ayesha Mukhtar
Naz, Ram
Mahmood, Muhammad Khurram
Uddin, Hafeez
GOMAL JOURNAL OF MEDICAL SCIENCES, 2020, 18 (01): : 24 - 29
[4] Serum Level of Matrix Metalloproteinase-9 in Patients with Head and Neck Squamous Cell Carcinoma
Stanciu, Adina E.
Zamfir-Chiru-Anton, Adina
Stanciu, Marcel M.
Popescu, Cristian R.
Gheorghe, Dan C.
CLINICAL LABORATORY, 2016, 62 (08) : 1569 - 1574
[5] Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
Vilen, Suvi-Tuuli
Salo, Tuula
Sorsa, Timo
Nyberg, Pia
SCIENTIFIC WORLD JOURNAL, 2013,
[6] Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma:: A potential marker for prognosis
Ruokolainen, H
Pääkkö, P
Turpeenniemi-Hujanen, T
CLINICAL CANCER RESEARCH, 2004, 10 (09) : 3110 - 3116
[7] Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
Zhou, C. X.
Gao, Y.
Johnson, N. W.
Gao, J.
AUSTRALIAN DENTAL JOURNAL, 2010, 55 (04) : 385 - 389
[8] Expression and clinical significance of matrix metal toproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma
de Vicente, JC
Fresno, MF
Villalain, L
Vega, JA
Vallelo, GH
ORAL ONCOLOGY, 2005, 41 (03) : 283 - 293
[9] ANALYSIS OF EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND METALLOPROTEINASE-9 IN HYPOPHARYNGEAL SQUAMOUS-CELL CARCINOMA BY IN-SITU HYBRIDIZATION
MIYAJIMA, Y
NAKANO, R
MORIMATSU, M
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1995, 104 (09): : 678 - 684
[10] Serum matrix metalloproteinase-9 in head and neck squamous cell carcinoma is a prognostic marker
Ruokolainen, H
Pääkkö, P
Turpeenniemi-Hujanen, T
INTERNATIONAL JOURNAL OF CANCER, 2005, 116 (03) : 422 - 427

← 1 2 3 4 5 →