The nucleophilic ring-opening of N-benzylquinuclidinium bromide

被引：10

作者：

Axelsson, O

Peters, D

机构：

[1] NeuroSearch A/S, DK-2600 Glostrup

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 02期

关键词：

D O I：

10.1002/jhet.5570340217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzylquinuclidinium bromide was ring opened by a series of heteronucleophiles, in the presence of cesium carbonate, to yield the corresponding N-benzyl-4-(2-hetero-ethyl)piperidines. The best yields were found with thiophenol (56%), phenol (55%), and benzimidazole (38%) as nucleophiles.

引用

页码：461 / 463

页数：3

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