Clinical Features and Prognosis According to Immunophenotypic Subtypes Including the Early T-Cell Precursor Subtype of T-Lymphoblastic Lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 Study

被引：6

作者：

Fukano, Reiji ^{[1
,2
]}

Sunami, Shosuke ^{[4
]}

Sekimizu, Masahiro ^{[3
]}

Takimoto, Tetsuya ^{[5
]}

Mori, Tetsuya ^{[8
]}

Mitsui, Tetsuo ^{[9
]}

Mori, Takeshi ^{[10
]}

Saito, Akiko Moriya ^{[3
]}

Watanabe, Tomoyuki ^{[11
]}

Ohshima, Koichi ^{[12
]}

Fujimoto, Junichiro ^{[5
]}

Nakazawa, Atsuko ^{[6
]}

Kiyokawa, Nobutaka ^{[5
,7
]}

Kobayashi, Ryoji ^{[13
]}

Horibe, Keizo ^{[3
]}

Tsurusawa, Masahito ^{[14
]}

机构：

[1] Natl Kyushu Canc Ctr, Dept Pediat, Fukuoka, Japan

[2] Nagoya Med Ctr, Natl Hosp Org, Clin Res Ctr, Nagoya, Aichi, Japan

[3] Nagoya Med Ctr, Natl Hosp Org, Dept Pediat, Nagoya, Aichi, Japan

[4] Japanese Red Cross Narita Hosp, Dept Pediat, Narita, Japan

[5] Clin Res Ctr, Tokyo, Japan

[6] Natl Ctr Child Hlth & Dev, Dept Pathol, Tokyo, Japan

[7] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan

[8] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa, Japan

[9] Yamagata Univ, Sch Med, Dept Pediat, Yamagata, Japan

[10] Kobe Univ, Grad Sch Med, Dept Pediat, Kobe, Hyogo, Japan

[11] Aichi Gakuin Univ, Fac Psychol Phys Sci, Dept Nutr Sci, Nisshin, Japan

[12] Kurume Univ, Sch Med, Dept Pathol, Kurume, Fukuoka, Japan

[13] Sapporo Hokuyu Hosp, Dept Pediat, Sapporo, Hokkaido, Japan

[14] Aichi Med Univ, Adv Med Res Ctr, Nagakute, Aichi, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 01期

关键词：

children; non-Hodgkin lymphoma; lymphoblastic lymphoma; immunophenotype; early T-cell; CHILDRENS ONCOLOGY GROUP; CHILDHOOD; LEUKEMIA; CLASSIFICATION; ADOLESCENTS; PROTOCOL; THERAPY;

D O I：

10.1097/MPH.0000000000000850

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We reviewed the immunophenotypic subtypes of pediatric T-cell lymphoblastic lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 study. Of the 104 patients, 40 patients each had sufficient data to evaluate the immunophenotypes and early T-cell precursor (ETP) subtype. Pro-T, pre-T, intermediate T, and mature T cells were observed in 1, 9, 21, and 9 cases, respectively. The 3-year event-free survival (EFS) rates of those with pro-T/pre-T, intermediate T, and mature T cells were 80.0 +/- 12.6%, 71.4 +/- 9.9%, and 88.9 +/- 10.5%, respectively (P = 0.546). There were 8 and 32 cases of ETP and non-ETP subtypes, with 3-year EFS rates of 75.0 +/- 15.3% and 71.9 +/- 8.0%, respectively (P = 0.828), indicating that the immunophenotypic subtype was not predictive of EFS in this study.

引用

页码：E34 / E37

页数：4

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