Viscoelasticity, mechanical properties, andin vivobiocompatibility of injectable polyvinyl alcohol/bioactive glass composite hydrogels as potential bone tissue scaffolds

被引:18
作者
Abd El-Fattah, Ahmed [1 ,2 ]
Hassan, Mohamad Nageeb [1 ,3 ]
Rashad, Ahmad [1 ,3 ]
Marei, Mona [4 ]
Kandil, Sherif [1 ]
机构
[1] Alexandria Univ, Inst Grad Studies & Res, Dept Mat Sci, Alexandria 21526, Egypt
[2] Univ Bahrain, Coll Sci, Dept Chem, POB 32038, Sakhir, Bahrain
[3] Alexandria Univ, Fac Dent, Dept Dent Biomat, Alexandria, Egypt
[4] Alexandria Univ, Fac Dent, Tissue Engn Labs, Alexandria, Egypt
关键词
Injectable hydrogel; poly(vinyl alcohol); bioactive glass; viscoelasticity; bone regeneration; BIOACTIVE GLASS;
D O I
10.1080/1023666X.2020.1790253
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
An injectable composite hydrogel composed of polyvinyl alcohol (PVA) and bioactive glass (BG) particles were synthesized by a physical crosslinking approach. The morphology, mechanical properties, and viscoelasticity of the PVA/BG composite hydrogel were characterized. Scanning electronic microscopy (SEM) showed uniform and homogeneous distribution of BG particles throughout the composite hydrogel. The incorporation of 2.5 wt% of BG particles in the composite hydrogel formulations, enhanced the static compressive strength and static elastic modulus by 325% and 150%, respectively. The storage molds (G ') was greater than the loss modules (G '') at all the frequency range studied, which revealed a self-standing elastic composite hydrogel with a smooth injectability. The PVA/BG composite hydrogel was also implanted subcutaneously in the dorsal region of adult male rats. After 4 weeks of implantation, no inflammatory cells were seen within and around the implant, which indicated that the composite hydrogel was biocompatible. The properties of the synthesized injectable PVA/BG composite hydrogel demonstrate its capability toward bone regeneration.
引用
收藏
页码:362 / 373
页数:12
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