The poxvirus C7L host range factor superfamily

被引:21
作者
Liu, Jia [1 ]
Rothenburg, Stefan [2 ]
McFadden, Grant [1 ]
机构
[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA
[2] Kansas State Univ, Lab Host Specif Virol, Div Biol, Manhattan, KS 66506 USA
关键词
PROTEIN-KINASE PKR; MYXOMA-VIRUS; TRANSLATION INITIATION; GENE; EVOLUTION; GENOME; IDENTIFICATION; CELLS; REPLICATION; DELETION;
D O I
10.1016/j.coviro.2012.09.012
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Host range factors, expressed by the poxvirus family, determine the host tropism of species, tissue, and cell specificity. C7L family members exist in the genomes of most sequenced mammalian poxviruses, suggesting an evolutionarily conserved effort adapting to the hosts. In general, C7L orthologs influence the host tropism in mammalian cell culture, and for some poxviruses it is essential for the complete viral life cycle in vitro and in vivo. The C7L family members lack obvious sequence homology with any other known viral or cellular proteins. Here we review recent findings from an evolutionary perspective and summarize recent progress that broadens our view on the role of C7L family members in mediating poxvirus host range and antagonizing the host defense system.
引用
收藏
页码:764 / 772
页数:9
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