Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics

被引：90

作者：

Nekrasov, Maxim ^{[1
]}

Amrichova, Jana ^{[1
]}

Parker, Brian J. ^{[1
]}

Soboleva, Tatiana A. ^{[1
]}

Jack, Cameron ^{[1
]}

Williams, Rohan ^{[1
]}

Huttley, Gavin A. ^{[1
]}

Tremethick, David J. ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 11期

基金：

英国医学研究理事会;

关键词：

NUCLEOSOME-FREE REGIONS; EARLY MAMMALIAN DEVELOPMENT; READ ALIGNMENT; HUMAN GENOME; MITOSIS; GENES;

D O I：

10.1038/nsmb.2424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although it has been clearly established that well-positioned histone H2A.Z-containing nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here that in mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming heterotypic (H2A.Z-H2A). To our surprise these nucleosomes remained heterotypic at M phase. At the TSS, we identified an unstable heterotypic histone H2A.Z-containing nucleosome in G1 phase that was lost after DNA replication. These dynamic changes at the TSS mirror a global expansion of the NDR at S and M phases, which, unexpectedly, is unrelated to transcriptional activity. Coincident with the loss of histone H2A.Z at promoters, histone H2A.Z is targeted to the centromere when mitosis begins.

引用

收藏

页码：1076 / +

页数：10

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