Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics

被引：89
作者：
Nekrasov, Maxim [1 ]
Amrichova, Jana [1 ]
Parker, Brian J. [1 ]
Soboleva, Tatiana A. [1 ]
Jack, Cameron [1 ]
Williams, Rohan [1 ]
Huttley, Gavin A. [1 ]
Tremethick, David J. [1 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 11期
基金：
英国医学研究理事会;
关键词：
NUCLEOSOME-FREE REGIONS; EARLY MAMMALIAN DEVELOPMENT; READ ALIGNMENT; HUMAN GENOME; MITOSIS; GENES;
D O I：
10.1038/nsmb.2424
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although it has been clearly established that well-positioned histone H2A.Z-containing nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here that in mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming heterotypic (H2A.Z-H2A). To our surprise these nucleosomes remained heterotypic at M phase. At the TSS, we identified an unstable heterotypic histone H2A.Z-containing nucleosome in G1 phase that was lost after DNA replication. These dynamic changes at the TSS mirror a global expansion of the NDR at S and M phases, which, unexpectedly, is unrelated to transcriptional activity. Coincident with the loss of histone H2A.Z at promoters, histone H2A.Z is targeted to the centromere when mitosis begins.
引用
收藏
页码：1076 / +
页数：10
相关论文
共 50 条
[21]   The histone variant H2A.Z and chromatin remodeler BRAHMA act coordinately and antagonistically to regulate transcription and nucleosome dynamics in Arabidopsis [J].
Torres, E. Shannon ;
Deal, Roger B. .
PLANT JOURNAL, 2019, 99 (01) :144-162
[22]   Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation [J].
Li, Zhaoyu ;
Gadue, Paul ;
Chen, Kaifu ;
Jiao, Yang ;
Tuteja, Geetu ;
Schug, Jonathan ;
Li, Wei ;
Kaestner, Klaus H. .
CELL, 2012, 151 (07) :1608-1616
[23]   Dual Role of the Histone Variant H2A.Z in Transcriptional Regulation of Stress-Response Genes [J].
Sura, Weronika ;
Kabza, Michal ;
Karlowski, Wojciech M. ;
Bieluszewski, Tomasz ;
Kus-Slowinska, Marta ;
Paweloszek, Lukasz ;
Sadowski, Jan ;
Ziolkowski, Piotr A. .
PLANT CELL, 2017, 29 (04) :791-807
[24]   Key Functional Regions in the Histone Variant H2A.Z C-Terminal Docking Domain [J].
Wang, Alice Y. ;
Aristizabal, Maria J. ;
Ryan, Colm ;
Krogan, Nevan J. ;
Kobor, Michael S. .
MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (18) :3871-3884
[25]   Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development [J].
Rangasamy, D ;
Berven, L ;
Ridgway, P ;
Tremethick, DJ .
EMBO JOURNAL, 2003, 22 (07) :1599-1607
[26]   The histone variant H2A.Z in yeast is almost exclusively incorporated into the+1 nucleosome in the direction of transcription [J].
Bagchi, Dia N. ;
Battenhouse, Anna M. ;
Park, Daechan ;
Iyer, Vishwanath R. .
NUCLEIC ACIDS RESEARCH, 2020, 48 (01) :157-170
[27]   Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z [J].
Mao, Zhuo ;
Pan, Lu ;
Wang, Weixiang ;
Sun, Jian ;
Shan, Shan ;
Dong, Qiang ;
Liang, Xiaoping ;
Dai, Linchang ;
Ding, Xiaojun ;
Chen, She ;
Zhang, Zhuqiang ;
Zhu, Bing ;
Zhou, Zheng .
CELL RESEARCH, 2014, 24 (04) :389-399
[28]   The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues [J].
Eirin-Lopez, Jose M. ;
Gonzalez-Romero, Rodrigo ;
Dryhurst, Deanna ;
Ishibashi, Toyotaka ;
Ausio, Juan .
BMC EVOLUTIONARY BIOLOGY, 2009, 9
[29]   H2A.Z Maintenance during Mitosis Reveals Nucleosome Shifting on Mitotically Silenced Genes [J].
Kelly, Theresa K. ;
Miranda, Tina Branscombe ;
Liang, Gangning ;
Berman, Benjamin P. ;
Lin, Joy C. ;
Tanay, Amos ;
Jones, Peter A. .
MOLECULAR CELL, 2010, 39 (06) :901-911
[30]   Chromatin Remodeling by Imitation Switch (ISWI) Class ATP-dependent Remodelers Is Stimulated by Histone Variant H2A.Z [J].
Goldman, Joseph A. ;
Garlick, Joseph D. ;
Kingston, Robert E. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (07) :4645-4651
12345