Effects of chronic exposure to γ-HCH (Lindane) on brain serotonergic and gabaergic systems, and serum cortisol and thyroxine levels of rainbow trout, Oncorhynchus mykiss

被引：22

作者：

Aldegunde, M ^{[1
]}

Soengas, JL ^{[1
]}

Ruibal, C ^{[1
]}

Andrés, MD ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Biol, Dept Fisiol, Lab Fisiol Anim, Santiago De Compostela 15706, Spain

来源：

FISH PHYSIOLOGY AND BIOCHEMISTRY | 1999年 / 20卷 / 04期

关键词：

GABA; serotonin;

D O I：

10.1023/A:1007795121340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rainbow trout (Oncorhynchus mykiss) were implanted intraperitoneally with 0.5 ml.100 g(-1) body weight of coconut oil alone (controls) or coconut oil contaning 0.05 mg of gamma-HCH (Lindane). After 18 days, changes in brain serotonin and GABA metabolism, as well as in serum cortisol and thyroxine levels, were measured. A lower final body weight was observed in gamma-HCH treated fish when compared with control fish. No significant differences were found for serum thyroxine levels between control and treated fish, but a significantly higher cortisol level was found in the gamma-HCH-implanted trout. Although GABA levels did not differ significantly in any brain region in the two treatment groups, the activity of the serotonergic system was significantly altered by the pesticide in both the hypothalamus and the telencephalon.

引用

页码：325 / 330

页数：6