Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders

被引：69

作者：

Delaby, C. ^{[1
,2
]}

Alcolea, D. ^{[2
,3
]}

Carmona-Iragui, M. ^{[2
,3
,4
]}

Illan-Gala, I. ^{[2
,3
]}

Morenas-Rodriguez, E. ^{[2
,3
]}

Barroeta, I ^{[2
,3
]}

Altuna, M. ^{[2
,3
]}

Estelles, T. ^{[2
,3
]}

Santos-Santos, M. ^{[2
,3
]}

Turon-Sans, J. ^{[5
,6
]}

Munoz, L. ^{[2
,3
]}

Ribosa-Nogue, R. ^{[2
,3
]}

Sala-Matavera, I ^{[2
,3
]}

Sanchez-Saudinos, B. ^{[2
,3
]}

Subirana, A. ^{[2
,3
]}

Videla, L. ^{[2
,3
,4
]}

Benejam, B. ^{[2
,3
,4
]}

Sirisi, S. ^{[2
,3
]}

Lehmann, S. ^{[1
]}

Belbin, O. ^{[2
,3
]}

Clarimon, J. ^{[2
,3
]}

Blesa, R. ^{[2
,3
]}

Pagonabarraga, J. ^{[3
,7
]}

Rojas-Garcia, R. ^{[5
,6
]}

Fortea, J. ^{[2
,3
,4
]}

Lleo, A. ^{[2
,3
]}

机构：

[1] Univ Montpellier, CHU Montpellier, Lab Biochim Proteom Clin, INSERM U1183, Montpellier, France

[2] Hosp Santa Creu & St Pau IIB St Pau, Dept Neurol, St Pau Memory Unit, Barcelona, Spain

[3] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Ciberned, Madrid, Spain

[4] Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain

[5] Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Dept Neurol,Neuromuscular Dis Unit,MND Clin, Barcelona, Spain

[6] Ctr Invest Biomed Red Enfermedades Raras, Ciberer, Madrid, Spain

[7] Hosp Santa Creu & St Pau IIB St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; LEWY BODIES; BIOMARKERS; DIAGNOSIS; CSF; DEMENTIA; BETA; INFLAMMATION;

D O I：

10.1038/s41598-020-66090-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In the present study, we analyzed NfL levels in the CSF of 535 participants of the SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We evaluated the differences in CSF NfL accross groups and its association with other CSF biomarkers and with cognitive scales. All neurogenerative diseases showed increased levels of CSF NfL, with the highest levels in patients with ALS, FTD, CBS and PSP. Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. These results have implications for the use of NfL as a marker in neurodegenerative diseases.

引用

页数：8

共 34 条

[1] Cerebrospinal Fluid Biomarkers in Patients with Frontotemporal Dementia Spectrum: A Single-Center Study [J].

Abu-Rumeileh, Samir ;

Mometto, Nicola ;

Bartoletti-Stella, Anna ;

Polischi, Barbara ;

Oppi, Federico ;

Poda, Roberto ;

Stanzani-Maserati, Michelangelo ;

Cortelli, Pietro ;

Liguori, Rocco ;

Capellari, Sabina ;

Parchi, Piero .

JOURNAL OF ALZHEIMERS DISEASE, 2018, 66 (02) :551-563

[2] The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders [J].

Alcolea, Daniel ;

Clarimon, Jordi ;

Carmona-Iragui, Maria ;

Illan-Gala, Ignacio ;

Morenas-Rodriguez, Estrella ;

Barroeta, Isabel ;

Ribosa-Nogue, Roser ;

Sala, Isabel ;

Sanchez-Saudinos, M. Belen ;

Videla, Laura ;

Subirana, Andrea ;

Benejam, Bessy ;

Valldeneu, Silvia ;

Fernandez, Susana ;

Estelles, Teresa ;

Altuna, Miren ;

Santos-Santos, Miguel ;

Garcia-Losada, Lidia ;

Bejanin, Alexandre ;

Pegueroles, Jordi ;

Montal, Victor ;

Vilaplana, Eduard ;

Belbin, Olivia ;

Dols-Icardo, Oriol ;

Sirisi, Sonia ;

Querol-Vilaseca, Marta ;

Cervera-Carles, Laura ;

Munoz, Laia ;

Nunez, Raul ;

Torres, Soraya ;

Camacho, M. Valle ;

Carrio, Ignasi ;

Gimenez, Sandra ;

Delaby, Constance ;

Rojas-Garcia, Ricard ;

Turon-Sans, Janina ;

Pagonabarraga, Javier ;

Jimenez, Amanda ;

Blesa, Rafael ;

Fortea, Juan ;

Lleo, Alberto .

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2019, 5 (01) :597-609

[3] CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration [J].

Alcolea, Daniel ;

Vilaplana, Eduard ;

Suarez-Calvet, Marc ;

Illan-Gala, Ignacio ;

Blesa, Rafael ;

Clarimon, Jordi ;

Llado, Albert ;

Sanchez-Valle, Raquel ;

Molinuevo, Jose L. ;

Garcia-Ribas, Guillermo ;

Compta, Yaroslau ;

Jose Marti, Maria ;

Pinol-Ripoll, Gerard ;

Amer-Ferrer, Guillermo ;

Noguera, Aina ;

Garcia-Martin, Ana ;

Fortea, Juan ;

Lleo, Alberto .

NEUROLOGY, 2017, 89 (02) :178-188

[4] Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease [J].

Alcolea, Daniel ;

Martinez-Lage, Pablo ;

Sanchez-Juan, Pascual ;

Olazaran, Javier ;

Antunez, Carmen ;

Izagirre, Andrea ;

Ecay-Torres, Mirian ;

Estanga, Ainara ;

Clerigue, Montserrat ;

Concepcion Guisasola, Maria ;

Sanchez Ruiz, Domingo ;

Marin Munoz, Juan ;

Calero, Miguel ;

Blesa, Rafael ;

Clarimon, Jordi ;

Carmona-Iragui, Maria ;

Morenas-Rodriguez, Estrella ;

Rodriguez-Rodriguez, Eloy ;

Vazquez Higuera, Jose Luis ;

Fortea, Juan ;

Lleo, Alberto .

NEUROLOGY, 2015, 85 (07) :626-633

[5] Relationship Between β-Secretase, Inflammation and Core Cerebrospinal Fluid Biomarkers for Alzheimer's Disease [J].

Alcolea, Daniel ;

Carmona-Iragui, Maria ;

Suarez-Calvet, Marc ;

Belen Sanchez-Saudinos, M. ;

Sala, Isabel ;

Anton-Aguirre, Sofia ;

Blesa, Rafael ;

Clarimon, Jordi ;

Fortea, Juan ;

Lleo, Alberto .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 42 (01) :157-167

[6] Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A Multicenter Study in Spain [J].

Alcolea, Daniel ;

Martinez-Lage, Pablo ;

Izagirre, Andrea ;

Clerigue, Montserrat ;

Carmona-Iragui, Maria ;

Alvarez, Rosa Maria ;

Fortea, Juan ;

Balasa, Mircea ;

Morenas-Rodriguez, Estrella ;

Llado, Albert ;

Grau, Oriol ;

Blennow, Kaj ;

Lleo, Alberto ;

Molinuevo, Jose L. .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 39 (04) :719-726

[7] Validation of amyloid-β peptides in CSF diagnosis of neurodegenerative dementias [J].

Bibl, M. ;

Mollenhauer, B. ;

Lewczuk, P. ;

Esselmann, H. ;

Wolf, S. ;

Trenkwalder, C. ;

Otto, M. ;

Stiens, G. ;

Ruether, E. ;

Kornhuber, J. ;

Wiltfang, J. .

MOLECULAR PSYCHIATRY, 2007, 12 (07) :671-680

[8] Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis [J].

Bridel, Claire ;

van Wieringen, Wessel N. ;

Zetterberg, Henrik ;

Tijms, Betty M. ;

Teunissen, Charlotte E. ;

Alvarez-Cermeno, Jose C. ;

Andreasson, Ulf ;

Axelsson, Markus ;

Backstrom, David C. ;

Bartos, Ales ;

Bjerke, Maria ;

Blennow, Kaj ;

Boxer, Adam ;

Brundin, Lou ;

Burman, Joachim ;

Christensen, Tove ;

Fialova, Lenka ;

Forsgren, Lars ;

Frederiksen, Jette L. ;

Gisslen, Magnus ;

Gray, Elizabeth ;

Gunnarsson, Martin ;

Hall, Sara ;

Hansson, Oskar ;

Herbert, Megan K. ;

Jakobsson, Joel ;

Jessen-Krut, Jan ;

Janelidze, Shorena ;

Johannsson, Gudmundur ;

Jonsson, Michael ;

Kappos, Ludwig ;

Khademi, Mohsen ;

Khalil, Michael ;

Kuhle, Jens ;

Landen, Mikael ;

Leinonen, Ville ;

Logroscino, Giancarlo ;

Lu, Ching-Hua ;

Lycke, Jan ;

Magdalinou, Nadia K. ;

Malaspina, Andrea ;

Mattsson, Niklas ;

Meeter, Lieke H. ;

Mehta, Sanjay R. ;

Modvig, Signe ;

Olsson, Tomas ;

Paterson, Ross W. ;

Perez-Santiago, Josue ;

Piehl, Fredrik ;

Pijnenburg, Yolande A. L. .

JAMA NEUROLOGY, 2019, 76 (09) :1035-1048

[9] El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis [J].

Brooks, BR ;

Miller, RG ;

Swash, M ;

Munsat, TL .

AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2000, 1 (05) :293-299

[10] Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease [J].

Carmona-Iragui, Maria ;

Balasa, Mircea ;

Benejam, Bessy ;

Alcolea, Daniel ;

Fernandez, Susana ;

Videla, Laura ;

Sala, Isabel ;

Belen Sanchez-Saudinos, Maria ;

Morenas-Rodriguez, Estrella ;

Ribosa-Nogue, Roser ;

Illan-Gala, Ignacio ;

Gonzalez-Ortiz, Sofia ;

Clarimon, Jordi ;

Schmitt, Frederick ;

Powell, David K. ;

Bosch, Beatriz ;

Llado, Albert ;

Rafii, Michael S. ;

Head, Elizabeth ;

Luis Molinuevo, Jose ;

Blesa, Rafael ;

Videla, Sebastian ;

Lleo, Alberto ;

Sanchez-Valle, Raquel ;

Fortea, Juan .

ALZHEIMERS & DEMENTIA, 2017, 13 (11) :1251-1260

← 1 2 3 4 →