Hyaluronan and phospholipids in boundary lubrication

被引：38
|
作者：
Liu, Chao [1 ]
Wang, Min [1 ]
An, Junxue [1 ]
Thormann, Esben [1 ]
Dedinaite, Andra [1 ,2 ]
机构：
[1] KTH Royal Inst Technol, Sch Chem Sci & Engn, Dept Chem Surface & Corros Sci, SE-10044 Stockholm, Sweden
[2] YKI Inst Surface Chem, SE-11486 Stockholm, Sweden
来源：
SOFT MATTER | 2012年 / 8卷 / 40期
关键词：
SURFACE FORCES APPARATUS; POLYMER; POLYELECTROLYTES;
D O I：
10.1039/c2sm26615f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Hyaluronan has been found to play an important role in boundary lubrication in joints, but model experiments have shown that free hyaluronan is reluctant to stay between surfaces. We show that hyaluronan, when assisted by a phospholipid bilayer, can act as a boundary lubricant, even at pressures well above those leading to breakdown of cartilage.
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页码：10241 / 10244
页数：4
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