Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits

被引：10

作者：

Aksenov, Daniil ^{[2
]}

Eassa, Joshua E. ^{[3
]}

Lakhoo, Janesh ^{[1
]}

Wyrwicz, Alice ^{[2
]}

Linsenmeier, Robert A. ^{[1
,4
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] NorthShore Univ HealthSyst, Ctr Bas MR Res, Dept Radiol, Evanston, IL USA

[3] Northwestern Univ, Program Biol Sci, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA

来源：

NEUROSCIENCE LETTERS | 2012年 / 524卷 / 02期

关键词：

Anesthesia; Barrel cortex; Hyperoxia; Oxygen; Rabbit; Autoregulation; BLOOD-FLOW; CARDIOPULMONARY BYPASS; ANESTHESIA; HYPEROXIA;

D O I：

10.1016/j.neulet.2012.07.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxygen tension (PO2) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, Delta PO2 (i.e.. hyperoxic PO2 minus baseline PO2) was computed. Compared to the conscious state, brain Delta PO2 increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：116 / 118

页数：3

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