Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits

被引：10
作者：
Aksenov, Daniil [2 ]
Eassa, Joshua E. [3 ]
Lakhoo, Janesh [1 ]
Wyrwicz, Alice [2 ]
Linsenmeier, Robert A. [1 ,4 ]
机构：
[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[2] NorthShore Univ HealthSyst, Ctr Bas MR Res, Dept Radiol, Evanston, IL USA
[3] Northwestern Univ, Program Biol Sci, Evanston, IL 60208 USA
[4] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA
来源：
NEUROSCIENCE LETTERS | 2012年 / 524卷 / 02期
关键词：
Anesthesia; Barrel cortex; Hyperoxia; Oxygen; Rabbit; Autoregulation; BLOOD-FLOW; CARDIOPULMONARY BYPASS; ANESTHESIA; HYPEROXIA;
D O I：
10.1016/j.neulet.2012.07.019
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Oxygen tension (PO2) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, Delta PO2 (i.e.. hyperoxic PO2 minus baseline PO2) was computed. Compared to the conscious state, brain Delta PO2 increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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页码：116 / 118
页数：3
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