Background: Atherosclerosis is a systemic multifocal disease with a preference for the branching points of the arteries. In this study, we quantitatively measured carotid and femoral plaque volume in subjects with cardiovascular risk factors (CVRF) and/or established atherosclerotic disease using a 3D ultrasound technique. Methods: In this prospective, single-centre study, we included 404 patients (median age 64; 56.9% men) with at least one CVRF or established cardiovascular disease. Plaque volume was measured using 3D ultrasound equipped with an automated software. Results: We found a strong correlation of plaque volume with CVRF and the number of vascular beds involved. The strongest associations with total and femoral plaque volume were noted for smoking, hypertension, age, as well as for the presence of peripheral arterial occlusive disease (p < 0.05). Carotid plaque volume was best predicted by hyperlipidaemia, hypertension, age, as well as the presence of cerebrovascular disease and coronary artery disease (p < 0.05). Conclusion: We conclude that smoking appears to be associated with total and femoral plaque volume, whereas hyperlipidaemia seems to be associated with carotid plaque volume. Measurement of 3D plaque volume is a practical and reproducible technique with the potential to become an additional screening tool in cardiovascular risk stratification.
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Baber, Usman
;
Mehran, Roxana
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Mehran, Roxana
;
Sartori, Samantha
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Sartori, Samantha
;
Schoos, Mikkel Malby
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, DK-2100 Copenhagen, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Schoos, Mikkel Malby
;
Sillesen, Henrik
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, DK-2100 Copenhagen, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Sillesen, Henrik
;
Muntendam, Pieter
论文数: 0引用数: 0
h-index: 0
机构:
ScPharmaceuticals, Lexington, MA USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Muntendam, Pieter
;
Garcia, Mario J.
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Div Cardiol, Bronx, NY 10467 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Garcia, Mario J.
;
Gregson, John
论文数: 0引用数: 0
h-index: 0
机构:
London Sch Hyg & Trop Med, London WC1, EnglandIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Gregson, John
;
Pocock, Stuart
论文数: 0引用数: 0
h-index: 0
机构:
London Sch Hyg & Trop Med, London WC1, EnglandIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Pocock, Stuart
;
Falk, Erling
论文数: 0引用数: 0
h-index: 0
机构:
Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Falk, Erling
;
Fuster, Valentin
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
机构:
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
D'Agostino, Ralph B.
;
Vasan, Ramachandran S.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Vasan, Ramachandran S.
;
Pencina, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Pencina, Michael J.
;
Wolf, Philip A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Wolf, Philip A.
;
Cobain, Mark
论文数: 0引用数: 0
h-index: 0
机构:Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Cobain, Mark
;
Massaro, Joseph M.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Biostat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Massaro, Joseph M.
;
Kannel, William B.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
机构:
Univ Vita Salute San Raffaele, Cardiol Dep, Milan, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Camici, Paolo
;
Gaemperli, Oliver
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Zurich USZ, Cardiol Dep, CH-8091 Zurich, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Gaemperli, Oliver
;
Di Valentino, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
Osped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
机构:
Erasmus MC Hosp, Thoraxctr, NL-3015 CE Rotterdam, NetherlandsOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Garcia-Garcia, Hector M.
;
Vlachopoulos, Charalambos
论文数: 0引用数: 0
h-index: 0
机构:
Hippokrateion Hosp, Athens Med Sch, Cardiol Dep, Athens 14575, GreeceOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Vlachopoulos, Charalambos
;
Cosentino, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Osped St Andrea, Cardiol Dep, I-00189 Rome, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Cosentino, Francesco
;
Windecker, Stephan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bern, Cardiol Dep, Inselspital, CH-3010 Bern, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Windecker, Stephan
;
Pedrazzini, Giovanni
论文数: 0引用数: 0
h-index: 0
机构:
Cardioctr Ticino CCT, Cardiol Dep, CH-6900 Lugano, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Pedrazzini, Giovanni
;
Conti, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florida, Hlth Sci Ctr, Cardiol Dep, Gainesville, FL 32610 USAOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Conti, Richard
;
Mach, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, CH-1211 Geneva, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Mach, Francois
;
De Caterina, Raffaele
论文数: 0引用数: 0
h-index: 0
机构:
Osped SS Annunziata, Univ Cardiol Dep, I-66013 Chieti, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
De Caterina, Raffaele
;
Libby, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham Womens Hosp, Boston, MA 02115 USAOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Baber, Usman
;
Mehran, Roxana
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Mehran, Roxana
;
Sartori, Samantha
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Sartori, Samantha
;
Schoos, Mikkel Malby
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, DK-2100 Copenhagen, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Schoos, Mikkel Malby
;
Sillesen, Henrik
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, DK-2100 Copenhagen, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Sillesen, Henrik
;
Muntendam, Pieter
论文数: 0引用数: 0
h-index: 0
机构:
ScPharmaceuticals, Lexington, MA USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Muntendam, Pieter
;
Garcia, Mario J.
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Div Cardiol, Bronx, NY 10467 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Garcia, Mario J.
;
Gregson, John
论文数: 0引用数: 0
h-index: 0
机构:
London Sch Hyg & Trop Med, London WC1, EnglandIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Gregson, John
;
Pocock, Stuart
论文数: 0引用数: 0
h-index: 0
机构:
London Sch Hyg & Trop Med, London WC1, EnglandIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Pocock, Stuart
;
Falk, Erling
论文数: 0引用数: 0
h-index: 0
机构:
Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, DenmarkIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
Falk, Erling
;
Fuster, Valentin
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA
机构:
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
D'Agostino, Ralph B.
;
Vasan, Ramachandran S.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Vasan, Ramachandran S.
;
Pencina, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Pencina, Michael J.
;
Wolf, Philip A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Wolf, Philip A.
;
Cobain, Mark
论文数: 0引用数: 0
h-index: 0
机构:Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
Cobain, Mark
;
Massaro, Joseph M.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Biostat, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
Massaro, Joseph M.
;
Kannel, William B.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02215 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USABoston Univ, Dept Math & Stat, Boston, MA 02215 USA
机构:
Univ Vita Salute San Raffaele, Cardiol Dep, Milan, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Camici, Paolo
;
Gaemperli, Oliver
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Zurich USZ, Cardiol Dep, CH-8091 Zurich, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Gaemperli, Oliver
;
Di Valentino, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
Osped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
机构:
Erasmus MC Hosp, Thoraxctr, NL-3015 CE Rotterdam, NetherlandsOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Garcia-Garcia, Hector M.
;
Vlachopoulos, Charalambos
论文数: 0引用数: 0
h-index: 0
机构:
Hippokrateion Hosp, Athens Med Sch, Cardiol Dep, Athens 14575, GreeceOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Vlachopoulos, Charalambos
;
Cosentino, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Osped St Andrea, Cardiol Dep, I-00189 Rome, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Cosentino, Francesco
;
Windecker, Stephan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bern, Cardiol Dep, Inselspital, CH-3010 Bern, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Windecker, Stephan
;
Pedrazzini, Giovanni
论文数: 0引用数: 0
h-index: 0
机构:
Cardioctr Ticino CCT, Cardiol Dep, CH-6900 Lugano, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Pedrazzini, Giovanni
;
Conti, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florida, Hlth Sci Ctr, Cardiol Dep, Gainesville, FL 32610 USAOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Conti, Richard
;
Mach, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, CH-1211 Geneva, SwitzerlandOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
Mach, Francois
;
De Caterina, Raffaele
论文数: 0引用数: 0
h-index: 0
机构:
Osped SS Annunziata, Univ Cardiol Dep, I-66013 Chieti, ItalyOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland
De Caterina, Raffaele
;
Libby, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham Womens Hosp, Boston, MA 02115 USAOsped San Giovanni Bellinzona, Cardiol Dep, CH-6500 Bellinzona, Switzerland