Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound

被引:18
作者
Noflatscher, Maria [1 ]
Schreinlechner, Michael [1 ]
Sommer, Philip [1 ]
Kerschbaum, Julia [2 ]
Berggren, Katharina [1 ,3 ]
Theurl, Markus [1 ]
Kirchmair, Rudolf [1 ]
Marschang, Peter [1 ,4 ]
机构
[1] Med Univ Innsbruck, Dept Internal Med 3, Cardiol, Angiol, Anichstr 35, A-6020 Innsbruck, Austria
[2] Med Univ Innsbruck, Dept Internal Med 4, Nephrol & Hypertens, Anichstr 35, A-6020 Innsbruck, Austria
[3] Clin Ctr Traunstein, Dept Internal Med, D-83278 Traunstein, Germany
[4] Cent Hosp Bolzano, Dept Internal Med, I-39100 Bolzano, Italy
关键词
cardiovascular risk factors; atherosclerosis; cardiovascular clinical research; ultrasound; INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; PREDICTIVE-VALUE; 3D ULTRASOUND; EVENTS; BURDEN; TOOL;
D O I
10.3390/jcm8010032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Atherosclerosis is a systemic multifocal disease with a preference for the branching points of the arteries. In this study, we quantitatively measured carotid and femoral plaque volume in subjects with cardiovascular risk factors (CVRF) and/or established atherosclerotic disease using a 3D ultrasound technique. Methods: In this prospective, single-centre study, we included 404 patients (median age 64; 56.9% men) with at least one CVRF or established cardiovascular disease. Plaque volume was measured using 3D ultrasound equipped with an automated software. Results: We found a strong correlation of plaque volume with CVRF and the number of vascular beds involved. The strongest associations with total and femoral plaque volume were noted for smoking, hypertension, age, as well as for the presence of peripheral arterial occlusive disease (p < 0.05). Carotid plaque volume was best predicted by hyperlipidaemia, hypertension, age, as well as the presence of cerebrovascular disease and coronary artery disease (p < 0.05). Conclusion: We conclude that smoking appears to be associated with total and femoral plaque volume, whereas hyperlipidaemia seems to be associated with carotid plaque volume. Measurement of 3D plaque volume is a practical and reproducible technique with the potential to become an additional screening tool in cardiovascular risk stratification.
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页数:11
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