Amphiphilic Homopolymer Vesicles as Unique Nano-Carriers for Cancer Therapy

被引：48
|
作者：
Mane, Shivshankar R. [2 ]
Rao, Vijayakameswara N. [2 ]
Chaterjee, Koushik [2 ]
Dinda, Himadri [2 ]
Nag, Soma [1 ]
Kishore, Abhinoy [1 ]
Das Sarma, Jayasri [1 ]
Shunmugam, Raja [2 ]
机构：
[1] Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Kolkata, India
[2] Indian Inst Sci Educ & Res Kolkata IISER K, Polymer Res Ctr, Dept Chem Sci, Kolkata, India
来源：
MACROMOLECULES | 2012年 / 45卷 / 19期
关键词：
POLYMER; DRUG; NANOPARTICLES; COPOLYMERS; MICELLES; SYSTEMS;
D O I：
10.1021/ma301644m
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A unique polymersome from amphiphilic, norbornene-derived thiobarbiturate homopolymers (NDTH) and its application as nanocarrier for cancer therapy are elaborately discussed. Various experiments like structural characterizations, control studies, cell viability studies, encapsulation studies, and MTT assay against 4T cancer cells are performed on these NDTH polymersomes to substantiate our claims. All of these results demonstrate that these self-assembled NDTH vesicles have great scope in the world of medicine, and they also symbolize promising carriers for the stimuli-triggered intracellular delivery of hydrophobic drugs.
引用
收藏
页码：8037 / 8042
页数：6
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